Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp.
Five new compounds called Pestalotis A–E (<b>1</b>–<b>5</b>), comprising three monoterpene-lactone compounds (<b>1</b>–<b>3</b>), one tetrahydrobenzofuran derivative (<b>4</b>), and one sesquiterpene (<b>5</b>), were isolated fr...
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MDPI AG
2021-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/23/7229 |
| _version_ | 1797507347420020736 |
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| author | Dan Zhao Meigeng Hu Guoxu Ma Xudong Xu |
| author_facet | Dan Zhao Meigeng Hu Guoxu Ma Xudong Xu |
| author_sort | Dan Zhao |
| collection | DOAJ |
| description | Five new compounds called Pestalotis A–E (<b>1</b>–<b>5</b>), comprising three monoterpene-lactone compounds (<b>1</b>–<b>3</b>), one tetrahydrobenzofuran derivative (<b>4</b>), and one sesquiterpene (<b>5</b>), were isolated from the EtOAc extract of <i>Pestalotiopsis</i> sp. The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. All compounds were tested for antitumor activity against SW-480, LoVo, HuH-7, and MCF-7. The results showed that compounds <b>2</b> and <b>4</b> exhibited potent antitumor activity against SW-480, LoVo, and HuH-7 cell lines. Furthermore, compound <b>4</b> was assessed against HuH-7, and the results indicated that the rate of apoptosis was dose-dependent. |
| first_indexed | 2024-03-10T04:47:13Z |
| format | Article |
| id | doaj.art-47a7596b3bd74108a43d540c62f06761 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T04:47:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-47a7596b3bd74108a43d540c62f067612023-11-23T02:49:30ZengMDPI AGMolecules1420-30492021-11-012623722910.3390/molecules26237229Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp.Dan Zhao0Meigeng Hu1Guoxu Ma2Xudong Xu3Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaFive new compounds called Pestalotis A–E (<b>1</b>–<b>5</b>), comprising three monoterpene-lactone compounds (<b>1</b>–<b>3</b>), one tetrahydrobenzofuran derivative (<b>4</b>), and one sesquiterpene (<b>5</b>), were isolated from the EtOAc extract of <i>Pestalotiopsis</i> sp. The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. All compounds were tested for antitumor activity against SW-480, LoVo, HuH-7, and MCF-7. The results showed that compounds <b>2</b> and <b>4</b> exhibited potent antitumor activity against SW-480, LoVo, and HuH-7 cell lines. Furthermore, compound <b>4</b> was assessed against HuH-7, and the results indicated that the rate of apoptosis was dose-dependent.https://www.mdpi.com/1420-3049/26/23/7229<i>Pestalotiopsis</i><i>Ligusticum chuanxiong</i>terpenescytotoxic activitiesHuH-7 cell lineslung cancer |
| spellingShingle | Dan Zhao Meigeng Hu Guoxu Ma Xudong Xu Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp. Molecules <i>Pestalotiopsis</i> <i>Ligusticum chuanxiong</i> terpenes cytotoxic activities HuH-7 cell lines lung cancer |
| title | Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp. |
| title_full | Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp. |
| title_fullStr | Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp. |
| title_full_unstemmed | Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp. |
| title_short | Five New Terpenes with Cytotoxic Activity from <i>Pestalotiopsis</i> sp. |
| title_sort | five new terpenes with cytotoxic activity from i pestalotiopsis i sp |
| topic | <i>Pestalotiopsis</i> <i>Ligusticum chuanxiong</i> terpenes cytotoxic activities HuH-7 cell lines lung cancer |
| url | https://www.mdpi.com/1420-3049/26/23/7229 |
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