Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians
Background: HIV is a chronic inflammatory state with the production of many acute-phase-reactant proteins. Some of these proteins have procoagulant activities that predispose HIV-infected patients to thrombosis. Objectives: The aim of the study was to evaluate the effects of HIV infection on the se...
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| Format: | Article |
| Language: | English |
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AOSIS
2021-08-01
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| Series: | Southern African Journal of HIV Medicine |
| Subjects: | |
| Online Access: | https://sajhivmed.org.za/index.php/hivmed/article/view/1253 |
| _version_ | 1818538325014740992 |
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| author | Fatai O. Bello Alani S. Akanmu Titilope A. Adeyemo Bukunmi M. Idowu Prosper Okonkwo Phyllis J. Kanki |
| author_facet | Fatai O. Bello Alani S. Akanmu Titilope A. Adeyemo Bukunmi M. Idowu Prosper Okonkwo Phyllis J. Kanki |
| author_sort | Fatai O. Bello |
| collection | DOAJ |
| description | Background: HIV is a chronic inflammatory state with the production of many acute-phase-reactant proteins. Some of these proteins have procoagulant activities that predispose HIV-infected patients to thrombosis.
Objectives: The aim of the study was to evaluate the effects of HIV infection on the serum levels of C4b-binding protein (C4BP) and protein S as markers of predisposition to thrombosis in HIV-infected adults.
Methods: The study population comprised of 61 HIV-infected adults on antiretroviral treatment (ART) who had achieved virological suppression, 58 HIV-infected adults not yet on ART and 59 HIV-negative healthy controls. The serum levels of free protein S, C4BP and the euglobulin clot lysis time (ECLT) were determined.
Results: The mean plasma-free protein S level of HIV-infected patients on ART (86.9% ± 25.8%) was significantly higher than that of treatment-naïve HIV-infected patients (75.7% ± 27.3%) (p = 0.005). Conversely, there was no statistically significant difference between the protein S levels of the HIV-infected subjects on ART (86.9% ± 25.8%) and those of the controls (94.9% ± 7.9%) (p = 0.119). The mean C4BP was significantly higher in the treatment-naïve HIV-infected subjects (36.7 ± 1.7 ng/dL) than that in those on ART (30.7 ± 2.6 ng/dL) and that in the controls (22.4 ± 2.4 ng/dL) (p 0.0001). Protein S deficiency was more prevalent among the subjects with elevated C4BP (p = 0.023). The mean ECLT was significantly more prolonged in the treatment-naïve HIV-infected subjects (241.9 ± 34.7 s) than controls (189.5 ± 40.7 s) (p 0.0001).
Conclusion: HIV infection causes elevated levels of C4BP and diminishes the serum levels of free protein S. We infer that the risk of thrombosis (as measured by these biomarkers) decreases with the use of antiretroviral drugs. |
| first_indexed | 2024-12-11T21:27:33Z |
| format | Article |
| id | doaj.art-47a7cc2c1b534f1d88779a86f4f660ae |
| institution | Directory Open Access Journal |
| issn | 1608-9693 2078-6751 |
| language | English |
| last_indexed | 2024-12-11T21:27:33Z |
| publishDate | 2021-08-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of HIV Medicine |
| spelling | doaj.art-47a7cc2c1b534f1d88779a86f4f660ae2022-12-22T00:50:16ZengAOSISSouthern African Journal of HIV Medicine1608-96932078-67512021-08-01221e1e710.4102/sajhivmed.v22i1.1253760Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult NigeriansFatai O. Bello0Alani S. Akanmu1Titilope A. Adeyemo2Bukunmi M. Idowu3Prosper Okonkwo4Phyllis J. Kanki5Department of Haematology and Blood Transfusion, Lagos University Teaching Hospital, Idi-Araba, Lagos StateDepartment of Haematology and Blood Transfusion, Lagos University Teaching Hospital, Idi-Araba, Lagos StateDepartment of Haematology and Blood Transfusion, Lagos University Teaching Hospital, Idi-Araba, Lagos StateDepartment of Radiology, Union Diagnostics and Clinical Services, Yaba, Lagos StateAPIN Public Health Initiatives, AbujaHarvard School of Public Health, Boston, Massachusetts, United States of AmericaBackground: HIV is a chronic inflammatory state with the production of many acute-phase-reactant proteins. Some of these proteins have procoagulant activities that predispose HIV-infected patients to thrombosis. Objectives: The aim of the study was to evaluate the effects of HIV infection on the serum levels of C4b-binding protein (C4BP) and protein S as markers of predisposition to thrombosis in HIV-infected adults. Methods: The study population comprised of 61 HIV-infected adults on antiretroviral treatment (ART) who had achieved virological suppression, 58 HIV-infected adults not yet on ART and 59 HIV-negative healthy controls. The serum levels of free protein S, C4BP and the euglobulin clot lysis time (ECLT) were determined. Results: The mean plasma-free protein S level of HIV-infected patients on ART (86.9% ± 25.8%) was significantly higher than that of treatment-naïve HIV-infected patients (75.7% ± 27.3%) (p = 0.005). Conversely, there was no statistically significant difference between the protein S levels of the HIV-infected subjects on ART (86.9% ± 25.8%) and those of the controls (94.9% ± 7.9%) (p = 0.119). The mean C4BP was significantly higher in the treatment-naïve HIV-infected subjects (36.7 ± 1.7 ng/dL) than that in those on ART (30.7 ± 2.6 ng/dL) and that in the controls (22.4 ± 2.4 ng/dL) (p 0.0001). Protein S deficiency was more prevalent among the subjects with elevated C4BP (p = 0.023). The mean ECLT was significantly more prolonged in the treatment-naïve HIV-infected subjects (241.9 ± 34.7 s) than controls (189.5 ± 40.7 s) (p 0.0001). Conclusion: HIV infection causes elevated levels of C4BP and diminishes the serum levels of free protein S. We infer that the risk of thrombosis (as measured by these biomarkers) decreases with the use of antiretroviral drugs.https://sajhivmed.org.za/index.php/hivmed/article/view/1253hivthrombosisprotein s deficiencyprotein c deficiencyc4b-binding proteinclot lysiseuglobulin clot lysis timetissue plasminogen activatorfibrinolysis |
| spellingShingle | Fatai O. Bello Alani S. Akanmu Titilope A. Adeyemo Bukunmi M. Idowu Prosper Okonkwo Phyllis J. Kanki Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians Southern African Journal of HIV Medicine hiv thrombosis protein s deficiency protein c deficiency c4b-binding protein clot lysis euglobulin clot lysis time tissue plasminogen activator fibrinolysis |
| title | Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians |
| title_full | Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians |
| title_fullStr | Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians |
| title_full_unstemmed | Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians |
| title_short | Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians |
| title_sort | derangement of protein s and c4b binding protein levels as acquired thrombophilia in hiv infected adult nigerians |
| topic | hiv thrombosis protein s deficiency protein c deficiency c4b-binding protein clot lysis euglobulin clot lysis time tissue plasminogen activator fibrinolysis |
| url | https://sajhivmed.org.za/index.php/hivmed/article/view/1253 |
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