A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates

A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates

Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhi...

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Bibliographic Details
Main Authors: Dorien De Pooter, Ellen Van Gulck, Antony Chen, Claire F. Evans, Jean-Marc Neefs, Helen Horton, Daniel Boden
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Vaccines
Subjects:
therapeutic vaccination
hepatitis B surface antigen (HBsAg)
hepatitis B virus (HBV) specific T-cells
HBV functional cure
non-human primate
electroporation
Online Access:https://www.mdpi.com/2076-393X/9/9/969

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