Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence
The use of Cannabis for medicinal purposes has been documented since ancient times, where one of its principal cannabinoids extracted from <i>Cannabis sativa</i>, cannabidiol (CBD), has emerged over the last few years as a promising molecule with anti-seizure potential. Here, we present...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/24/16181 |
| _version_ | 1797457193510895616 |
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| author | Cecilia Zavala-Tecuapetla Hiram Luna-Munguia María-Leonor López-Meraz Manola Cuellar-Herrera |
| author_facet | Cecilia Zavala-Tecuapetla Hiram Luna-Munguia María-Leonor López-Meraz Manola Cuellar-Herrera |
| author_sort | Cecilia Zavala-Tecuapetla |
| collection | DOAJ |
| description | The use of Cannabis for medicinal purposes has been documented since ancient times, where one of its principal cannabinoids extracted from <i>Cannabis sativa</i>, cannabidiol (CBD), has emerged over the last few years as a promising molecule with anti-seizure potential. Here, we present an overview of recent literature pointing out CBD’s pharmacological profile (solubility, metabolism, drug-drug interactions, etc.,), CBD’s interactions with multiple molecular targets as well as advances in preclinical research concerning its anti-seizure effect on both acute seizure models and chronic models of epilepsy. We also highlight the recent attention that has been given to other natural cannabinoids and to synthetic derivatives of CBD as possible compounds with therapeutic anti-seizure potential. All the scientific research reviewed here encourages to continue to investigate the probable therapeutic efficacy of CBD and its related compounds not only in epilepsy but also and specially in drug-resistant epilepsy, since there is a dire need for new and effective drugs to treat this disease. |
| first_indexed | 2024-03-09T16:18:41Z |
| format | Article |
| id | doaj.art-47ab0f04345b4435a0d3b978669d646e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:18:41Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-47ab0f04345b4435a0d3b978669d646e2023-11-24T15:34:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241618110.3390/ijms232416181Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical EvidenceCecilia Zavala-Tecuapetla0Hiram Luna-Munguia1María-Leonor López-Meraz2Manola Cuellar-Herrera3Laboratory of Physiology of Reticular Formation, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, La Fama, Mexico City 14269, MexicoDepartamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus UNAM-Juriquilla, Queretaro 76230, MexicoInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa 91190, MexicoEpilepsy Clinic, Hospital General de México Dr. Eduardo Liceaga, Dr. Balmis 148, Doctores, Mexico City 06720, MexicoThe use of Cannabis for medicinal purposes has been documented since ancient times, where one of its principal cannabinoids extracted from <i>Cannabis sativa</i>, cannabidiol (CBD), has emerged over the last few years as a promising molecule with anti-seizure potential. Here, we present an overview of recent literature pointing out CBD’s pharmacological profile (solubility, metabolism, drug-drug interactions, etc.,), CBD’s interactions with multiple molecular targets as well as advances in preclinical research concerning its anti-seizure effect on both acute seizure models and chronic models of epilepsy. We also highlight the recent attention that has been given to other natural cannabinoids and to synthetic derivatives of CBD as possible compounds with therapeutic anti-seizure potential. All the scientific research reviewed here encourages to continue to investigate the probable therapeutic efficacy of CBD and its related compounds not only in epilepsy but also and specially in drug-resistant epilepsy, since there is a dire need for new and effective drugs to treat this disease.https://www.mdpi.com/1422-0067/23/24/16181cannabidiolpreclinical modelsseizureepilepsydrug resistant epilepsyphytocannabinoids |
| spellingShingle | Cecilia Zavala-Tecuapetla Hiram Luna-Munguia María-Leonor López-Meraz Manola Cuellar-Herrera Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence International Journal of Molecular Sciences cannabidiol preclinical models seizure epilepsy drug resistant epilepsy phytocannabinoids |
| title | Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence |
| title_full | Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence |
| title_fullStr | Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence |
| title_full_unstemmed | Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence |
| title_short | Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence |
| title_sort | advances and challenges of cannabidiol as an anti seizure strategy preclinical evidence |
| topic | cannabidiol preclinical models seizure epilepsy drug resistant epilepsy phytocannabinoids |
| url | https://www.mdpi.com/1422-0067/23/24/16181 |
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