Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies
Pregnancy after lung and heart–lung transplantation remains rare. This French study deals with change in lung function after a pregnancy and the maternal and newborn outcomes. We retrospectively included 39 pregnancies in 35 women aged >20 years. Data on patients, course of pregnancies and newbor...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2019-10-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/5/4/00254-2018.full |
| _version_ | 1811214924056100864 |
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| author | Charlotte Bry Dominique Hubert Martine Reynaud-Gaubert Claire Dromer Hervé Mal Antoine Roux Véronique Boussaud Johanna Claustre Jérôme Le Pavec Muriel Murris-Espin Isabelle Danner-Boucher |
| author_facet | Charlotte Bry Dominique Hubert Martine Reynaud-Gaubert Claire Dromer Hervé Mal Antoine Roux Véronique Boussaud Johanna Claustre Jérôme Le Pavec Muriel Murris-Espin Isabelle Danner-Boucher |
| author_sort | Charlotte Bry |
| collection | DOAJ |
| description | Pregnancy after lung and heart–lung transplantation remains rare. This French study deals with change in lung function after a pregnancy and the maternal and newborn outcomes. We retrospectively included 39 pregnancies in 35 women aged >20 years. Data on patients, course of pregnancies and newborns were collected from nine transplantation centres. Mean age at time of pregnancy was 28 years. Cystic fibrosis affected 71% of patients. Mean±sd time between transplantation and pregnancy was 63±44 months. 26 births occurred (67%) with a mean term of 36 weeks of amenorrhoea and a mean birthweight of 2409 g. Prematurity was observed in 11 cases (43%). Forced expiratory volume in 1 s was 83.9% of predicted before pregnancy and 77.3% of predicted 1 year after the end of pregnancy (p=0.04). 10 patients developed chronic lung allograft dysfunction after delivery. Nine patients died at a mean±sd time after transplantation of 8.2±7 years and a mean±sd time after pregnancy of 4.6±6.5 years. These data show that pregnancy remains feasible in lung and heart–lung transplant recipients, with more frequent maternal and newborn complications than in the general population. Survival in this cohort appears to be similar to the global survival observed in lung transplant recipients. Planned pregnancy and multidisciplinary follow-up are crucial. |
| first_indexed | 2024-04-12T06:12:41Z |
| format | Article |
| id | doaj.art-47ab3bd9041143a69768022062f3e0a6 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-04-12T06:12:41Z |
| publishDate | 2019-10-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-47ab3bd9041143a69768022062f3e0a62022-12-22T03:44:39ZengEuropean Respiratory SocietyERJ Open Research2312-05412019-10-015410.1183/23120541.00254-201800254-2018Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnanciesCharlotte Bry0Dominique Hubert1Martine Reynaud-Gaubert2Claire Dromer3Hervé Mal4Antoine Roux5Véronique Boussaud6Johanna Claustre7Jérôme Le Pavec8Muriel Murris-Espin9Isabelle Danner-Boucher10 Service de Pneumologie, CHU de Nantes, Nantes, France Service de Pneumologie, Hôpital Cochin, Paris, France Centre de Ressource et de Compétences de la Mucoviscidose Adulte, Equipe de Transplantation Pulmonaire, CHU Nord, Marseille, France Service de Pneumologie, CHU de Bordeaux, Bordeaux, France Service de Pneumologie, Hôpital Bichat-Claude Bernard, Paris, France Service de Pneumologie, Hôpital Foch, Suresnes, France Service de Pneumologie, Hôpital Européen Georges Pompidou, Paris, France Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, CHU de Grenoble, Grenoble, France Service de Chirurgie Thoracique et Vasculaire, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France CRCM Adulte, Service de Pneumologie-Allergologie, CHU de Toulouse, Toulouse, France Service de Pneumologie, CHU de Nantes, Nantes, France Pregnancy after lung and heart–lung transplantation remains rare. This French study deals with change in lung function after a pregnancy and the maternal and newborn outcomes. We retrospectively included 39 pregnancies in 35 women aged >20 years. Data on patients, course of pregnancies and newborns were collected from nine transplantation centres. Mean age at time of pregnancy was 28 years. Cystic fibrosis affected 71% of patients. Mean±sd time between transplantation and pregnancy was 63±44 months. 26 births occurred (67%) with a mean term of 36 weeks of amenorrhoea and a mean birthweight of 2409 g. Prematurity was observed in 11 cases (43%). Forced expiratory volume in 1 s was 83.9% of predicted before pregnancy and 77.3% of predicted 1 year after the end of pregnancy (p=0.04). 10 patients developed chronic lung allograft dysfunction after delivery. Nine patients died at a mean±sd time after transplantation of 8.2±7 years and a mean±sd time after pregnancy of 4.6±6.5 years. These data show that pregnancy remains feasible in lung and heart–lung transplant recipients, with more frequent maternal and newborn complications than in the general population. Survival in this cohort appears to be similar to the global survival observed in lung transplant recipients. Planned pregnancy and multidisciplinary follow-up are crucial.http://openres.ersjournals.com/content/5/4/00254-2018.full |
| spellingShingle | Charlotte Bry Dominique Hubert Martine Reynaud-Gaubert Claire Dromer Hervé Mal Antoine Roux Véronique Boussaud Johanna Claustre Jérôme Le Pavec Muriel Murris-Espin Isabelle Danner-Boucher Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies ERJ Open Research |
| title | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
| title_full | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
| title_fullStr | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
| title_full_unstemmed | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
| title_short | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
| title_sort | pregnancy after lung and heart lung transplantation a french multicentre retrospective study of 39 pregnancies |
| url | http://openres.ersjournals.com/content/5/4/00254-2018.full |
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