A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants
Recently, Zuotin-related factor 1 (ZRF1), an epigenetic regulator, was found to be involved in transcriptional regulation. In animals and humans, ZRF1 specifically binds to monoubiquitinated histone H2A through a ubiquitin-binding domain and derepresses Polycomb target genes at the beginning of cell...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/8/1245 |
| _version_ | 1797523761895833600 |
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| author | Jing Feng Yahui Gao Kun Wang Mingguo Jiang |
| author_facet | Jing Feng Yahui Gao Kun Wang Mingguo Jiang |
| author_sort | Jing Feng |
| collection | DOAJ |
| description | Recently, Zuotin-related factor 1 (ZRF1), an epigenetic regulator, was found to be involved in transcriptional regulation. In animals and humans, ZRF1 specifically binds to monoubiquitinated histone H2A through a ubiquitin-binding domain and derepresses Polycomb target genes at the beginning of cellular differentiation. In addition, ZRF1 can work as a tumor suppressor. According to bioinformatics analysis, ZRF1 homologs are widely found in plants. However, the current studies on ZRF1 in higher plants are limited and few in-depth studies of its functions have been reported. In this review, we aim to summarize the key role of AtZRF1a/b in <i>Arabidopsis thaliana</i> growth and development, as well as the research progress in this field in recent years. |
| first_indexed | 2024-03-10T08:47:39Z |
| format | Article |
| id | doaj.art-47abc7c0ad024f9ab84d3f7cae83e5a8 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T08:47:39Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-47abc7c0ad024f9ab84d3f7cae83e5a82023-11-22T07:46:37ZengMDPI AGGenes2073-44252021-08-01128124510.3390/genes12081245A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in PlantsJing Feng0Yahui Gao1Kun Wang2Mingguo Jiang3Guangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Nanning 530008, ChinaGuangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Nanning 530008, ChinaGuangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Nanning 530008, ChinaGuangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Nanning 530008, ChinaRecently, Zuotin-related factor 1 (ZRF1), an epigenetic regulator, was found to be involved in transcriptional regulation. In animals and humans, ZRF1 specifically binds to monoubiquitinated histone H2A through a ubiquitin-binding domain and derepresses Polycomb target genes at the beginning of cellular differentiation. In addition, ZRF1 can work as a tumor suppressor. According to bioinformatics analysis, ZRF1 homologs are widely found in plants. However, the current studies on ZRF1 in higher plants are limited and few in-depth studies of its functions have been reported. In this review, we aim to summarize the key role of AtZRF1a/b in <i>Arabidopsis thaliana</i> growth and development, as well as the research progress in this field in recent years.https://www.mdpi.com/2073-4425/12/8/1245ZRF1<i>Arabidopsis thaliana</i>stem cell maintenanceembryo developmentmonoubiquitination |
| spellingShingle | Jing Feng Yahui Gao Kun Wang Mingguo Jiang A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants Genes ZRF1 <i>Arabidopsis thaliana</i> stem cell maintenance embryo development monoubiquitination |
| title | A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants |
| title_full | A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants |
| title_fullStr | A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants |
| title_full_unstemmed | A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants |
| title_short | A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants |
| title_sort | novel epigenetic regulator zrf1 insight into its functions in plants |
| topic | ZRF1 <i>Arabidopsis thaliana</i> stem cell maintenance embryo development monoubiquitination |
| url | https://www.mdpi.com/2073-4425/12/8/1245 |
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