The potential use of biomarkers in predicting contrast-induced acute kidney injury
Michele Andreucci,1 Teresa Faga,1 Eleonora Riccio,2 Massimo Sabbatini,2 Antonio Pisani,2 Ashour Michael,1 1Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, 2Department of Public Health, University of Naples Federico II, Naples, Italy Abstract: Co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-09-01
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| Series: | International Journal of Nephrology and Renovascular Disease |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-potential-use-of-biomarkers-in-predicting-contrast-induced-acute-k-peer-reviewed-article-IJNRD |
| _version_ | 1818952248408932352 |
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| author | Andreucci M Faga T Riccio E Sabbatini M Pisani A Michael A |
| author_facet | Andreucci M Faga T Riccio E Sabbatini M Pisani A Michael A |
| author_sort | Andreucci M |
| collection | DOAJ |
| description | Michele Andreucci,1 Teresa Faga,1 Eleonora Riccio,2 Massimo Sabbatini,2 Antonio Pisani,2 Ashour Michael,1 1Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, 2Department of Public Health, University of Naples Federico II, Naples, Italy Abstract: Contrast-induced acute kidney injury (CI-AKI) is a problem associated with the use of iodinated contrast media, causing kidney dysfunction in patients with preexisting renal failure. It accounts for 12% of all hospital-acquired kidney failure and increases the length of hospitalization, a situation that is worsening with increasing numbers of patients with comorbidities, including those requiring cardiovascular interventional procedures. So far, its diagnosis has relied upon the rise in creatinine levels, which is a late marker of kidney damage and is believed to be inadequate. Therefore, there is an urgent need for biomarkers that can detect CI-AKI sooner and more reliably. In recent years, many new biomarkers have been characterized for AKI, and these are discussed particularly with their use in known CI-AKI models and studies and include neutrophil gelatinase-associated lipocalin, cystatin C (Cys-C), kidney injury molecule-1, interleukin-18, N-acetyl-β-d-glucosaminidase, and L-type fatty acid-binding protein (L-FABP). The potential of miRNA and metabolomic technology is also mentioned. Early detection of CI-AKI may lead to early intervention and therefore improve patient outcome, and in future any one or a combination of several of these markers together with development in technology for their analysis may prove effective in this respect. Keywords: radiocontrast media, acute renal failure, markers, renal injury |
| first_indexed | 2024-12-20T09:47:22Z |
| format | Article |
| id | doaj.art-47ac896b92eb4c6dbbce384dd394a2c7 |
| institution | Directory Open Access Journal |
| issn | 1178-7058 |
| language | English |
| last_indexed | 2024-12-20T09:47:22Z |
| publishDate | 2016-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nephrology and Renovascular Disease |
| spelling | doaj.art-47ac896b92eb4c6dbbce384dd394a2c72022-12-21T19:44:42ZengDove Medical PressInternational Journal of Nephrology and Renovascular Disease1178-70582016-09-01Volume 920522128827The potential use of biomarkers in predicting contrast-induced acute kidney injuryAndreucci MFaga TRiccio ESabbatini MPisani AMichael AMichele Andreucci,1 Teresa Faga,1 Eleonora Riccio,2 Massimo Sabbatini,2 Antonio Pisani,2 Ashour Michael,1 1Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, 2Department of Public Health, University of Naples Federico II, Naples, Italy Abstract: Contrast-induced acute kidney injury (CI-AKI) is a problem associated with the use of iodinated contrast media, causing kidney dysfunction in patients with preexisting renal failure. It accounts for 12% of all hospital-acquired kidney failure and increases the length of hospitalization, a situation that is worsening with increasing numbers of patients with comorbidities, including those requiring cardiovascular interventional procedures. So far, its diagnosis has relied upon the rise in creatinine levels, which is a late marker of kidney damage and is believed to be inadequate. Therefore, there is an urgent need for biomarkers that can detect CI-AKI sooner and more reliably. In recent years, many new biomarkers have been characterized for AKI, and these are discussed particularly with their use in known CI-AKI models and studies and include neutrophil gelatinase-associated lipocalin, cystatin C (Cys-C), kidney injury molecule-1, interleukin-18, N-acetyl-β-d-glucosaminidase, and L-type fatty acid-binding protein (L-FABP). The potential of miRNA and metabolomic technology is also mentioned. Early detection of CI-AKI may lead to early intervention and therefore improve patient outcome, and in future any one or a combination of several of these markers together with development in technology for their analysis may prove effective in this respect. Keywords: radiocontrast media, acute renal failure, markers, renal injuryhttps://www.dovepress.com/the-potential-use-of-biomarkers-in-predicting-contrast-induced-acute-k-peer-reviewed-article-IJNRDRadiocontrast mediaacute renal failuremarkersrenal injury. |
| spellingShingle | Andreucci M Faga T Riccio E Sabbatini M Pisani A Michael A The potential use of biomarkers in predicting contrast-induced acute kidney injury International Journal of Nephrology and Renovascular Disease Radiocontrast media acute renal failure markers renal injury. |
| title | The potential use of biomarkers in predicting contrast-induced acute kidney injury |
| title_full | The potential use of biomarkers in predicting contrast-induced acute kidney injury |
| title_fullStr | The potential use of biomarkers in predicting contrast-induced acute kidney injury |
| title_full_unstemmed | The potential use of biomarkers in predicting contrast-induced acute kidney injury |
| title_short | The potential use of biomarkers in predicting contrast-induced acute kidney injury |
| title_sort | potential use of biomarkers in predicting contrast induced acute kidney injury |
| topic | Radiocontrast media acute renal failure markers renal injury. |
| url | https://www.dovepress.com/the-potential-use-of-biomarkers-in-predicting-contrast-induced-acute-k-peer-reviewed-article-IJNRD |
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