Co-Combination of Pregabalin and <i>Withania</i> <i>coagulans</i>-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

Co-Combination of Pregabalin and <i>Withania</i> <i>coagulans</i>-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

The current study reports the fabrication of co-combination gel using Pregabalin and <i>Withania coagulans</i> fruit extract to validate its effectiveness for neuropathic pain in chronic constriction injury (CCI) rat models. Three topical gels were prepared using Carbopol 934 through a p...

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Bibliographic Details
Main Authors: Anam Asghar, Muhammad Naeem Aamir, Fatima Akbar Sheikh, Naveed Ahmad, Mervat A. Elsherif, Syed Nasir Abbas Bukhari
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
co-combination gel
pregabalin
<i>Withania coagulans</i> extract
chronic constriction injury
topical delivery
Online Access:https://www.mdpi.com/1420-3049/27/14/4433

Internet

https://www.mdpi.com/1420-3049/27/14/4433

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