Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis
<p><strong>Objective</strong> To compare the sensitivity and specificity of ice test, neostigmine test and single fiber electromyography (SFEMG) in the diagnosis of ocular myasthenia gravis (OMG), so as to establish an appropriate process for the diagnosis of OMG. <strong>...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2016-10-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1487 |
| _version_ | 1818888082236112896 |
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| author | Fu-ru LIANG Tian-you ZHANG Gui-juan YAO Yan-hong JIA Jing LI Guo-rong LIU |
| author_facet | Fu-ru LIANG Tian-you ZHANG Gui-juan YAO Yan-hong JIA Jing LI Guo-rong LIU |
| author_sort | Fu-ru LIANG |
| collection | DOAJ |
| description | <p><strong>Objective</strong> To compare the sensitivity and specificity of ice test, neostigmine test and single fiber electromyography (SFEMG) in the diagnosis of ocular myasthenia gravis (OMG), so as to establish an appropriate process for the diagnosis of OMG. <strong>Methods</strong> A total of 116 patients with newly onset ptosis and/or diplopia were detected by ice test, neostigmine test and SFEMG. Patients were followed up for 6 months to observe the disease changes and experimental treatment effects. <strong>Results</strong> Apart from patients whose diagnosis was in doubt or lost to follow - up, and who were diagnosed as generalized myasthenia gravis (GMG), the definite diagnosis was finally made in 81 patients, including 21 OMG patients and 60 patients with ptosis and/or diplopia caused by other diseases. The sensitivity of ice test for diagnosis of OMG was 95.24% (20/21), and specificity was 98.33%(59/60). The sensitivity of neostigmine test for diagnosis of OMG was 90.48% (19/21), and specificity was 85% (51/60). The sensitivity of SFEMG for diagnosis of OMG was 95.24% (20/21), and specificity was 80% (48/60). Among 3 tests, only specificity was found significant difference (<em>χ<sup>2</sup></em> = 5.232, <em>P</em> = 0.022). The specificity of ice test was better than that of neostigmine test (<em>χ<sup>2</sup></em> = 5.707, <em>P</em> = 0.017) and SFEMG (<em>χ<sup>2</sup></em> = 6.023, <em>P</em> = 0.014). <strong>Conclusions</strong> The ice test achieved high sensitivity and specificity in the diagnosis of OMG. The combination of ice test, neostigmine test and SFEMG may have important clinical value for the early diagnosis of OMG.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.10.008</p> |
| first_indexed | 2024-12-19T16:47:28Z |
| format | Article |
| id | doaj.art-47b02a18895f4d528510dae3c7577bd2 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-19T16:47:28Z |
| publishDate | 2016-10-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-47b02a18895f4d528510dae3c7577bd22022-12-21T20:13:37ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312016-10-0116106846881457Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravisFu-ru LIANG0Tian-you ZHANG1Gui-juan YAO2Yan-hong JIA3Jing LI4Guo-rong LIU5Department of Neurology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, ChinaDepartment of Neurology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, ChinaDepartment of Ophthalmology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, ChinaDepartment of Neurology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, ChinaDepartment of Neurology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, ChinaDepartment of Neurology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China<p><strong>Objective</strong> To compare the sensitivity and specificity of ice test, neostigmine test and single fiber electromyography (SFEMG) in the diagnosis of ocular myasthenia gravis (OMG), so as to establish an appropriate process for the diagnosis of OMG. <strong>Methods</strong> A total of 116 patients with newly onset ptosis and/or diplopia were detected by ice test, neostigmine test and SFEMG. Patients were followed up for 6 months to observe the disease changes and experimental treatment effects. <strong>Results</strong> Apart from patients whose diagnosis was in doubt or lost to follow - up, and who were diagnosed as generalized myasthenia gravis (GMG), the definite diagnosis was finally made in 81 patients, including 21 OMG patients and 60 patients with ptosis and/or diplopia caused by other diseases. The sensitivity of ice test for diagnosis of OMG was 95.24% (20/21), and specificity was 98.33%(59/60). The sensitivity of neostigmine test for diagnosis of OMG was 90.48% (19/21), and specificity was 85% (51/60). The sensitivity of SFEMG for diagnosis of OMG was 95.24% (20/21), and specificity was 80% (48/60). Among 3 tests, only specificity was found significant difference (<em>χ<sup>2</sup></em> = 5.232, <em>P</em> = 0.022). The specificity of ice test was better than that of neostigmine test (<em>χ<sup>2</sup></em> = 5.707, <em>P</em> = 0.017) and SFEMG (<em>χ<sup>2</sup></em> = 6.023, <em>P</em> = 0.014). <strong>Conclusions</strong> The ice test achieved high sensitivity and specificity in the diagnosis of OMG. The combination of ice test, neostigmine test and SFEMG may have important clinical value for the early diagnosis of OMG.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.10.008</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1487Myasthenia gravisBlepharoptosisDiplopiaIce test (not in MeSH)NeostigmineElectromyography |
| spellingShingle | Fu-ru LIANG Tian-you ZHANG Gui-juan YAO Yan-hong JIA Jing LI Guo-rong LIU Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis Chinese Journal of Contemporary Neurology and Neurosurgery Myasthenia gravis Blepharoptosis Diplopia Ice test (not in MeSH) Neostigmine Electromyography |
| title | Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis |
| title_full | Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis |
| title_fullStr | Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis |
| title_full_unstemmed | Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis |
| title_short | Comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis |
| title_sort | comparative study on the value of accessory examinations in the diagnosis of ocular myasthenia gravis |
| topic | Myasthenia gravis Blepharoptosis Diplopia Ice test (not in MeSH) Neostigmine Electromyography |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/1487 |
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