Back to basics: review on vitamin D and respiratory viral infections including COVID-19
Importance As the scientific community is in a marathon in finding out the cure for COVID-19, in this crisis, it is essential for the physicians not to forget about the basics. Due to the pandemic crisis, in many nursing homes and hospitals, there established new policies on decreasing unnecessary m...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Greater Baltimore Medical Center
2020-11-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2020.1811074 |
| _version_ | 1797966398402592768 |
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| author | Mamtha Balla Ganesh Prasad Merugu Venu Madhav Konala Vikram Sangani Hema Kondakindi Mytri Pokal Vijay Gayam Sreedhar Adapa Srikanth Naramala Srikrishna V Malayala |
| author_facet | Mamtha Balla Ganesh Prasad Merugu Venu Madhav Konala Vikram Sangani Hema Kondakindi Mytri Pokal Vijay Gayam Sreedhar Adapa Srikanth Naramala Srikrishna V Malayala |
| author_sort | Mamtha Balla |
| collection | DOAJ |
| description | Importance As the scientific community is in a marathon in finding out the cure for COVID-19, in this crisis, it is essential for the physicians not to forget about the basics. Due to the pandemic crisis, in many nursing homes and hospitals, there established new policies on decreasing unnecessary medications to minimize cross-contamination. Sometimes these policies are making providers avoid essential drugs such as Vitamins, including Vitamin D. In this paper, we try to emphasize the importance of Vitamin D in COVID-19 and respiratory viral patients. Relevance Vitamin D helps in decreasing the ‘pro-inflammatory cytokines’ in the lungs and acts in immunomodulatory function, and ‘also it will increase the anti-inflammatory, antiviral responses of the respiratory epithelial cells during infection.’ Conclusion Due to the highly contagious nature of COVID-19 and the increased morbidity and mortality with no appropriate therapy and vaccine, one must be cautious and do everything to help COVID-19 patients. In hospitals and other health care settings to decrease cross-contamination, holding other non-essential medications is taking place. Discontinuing Vitamins could increase the mortality and morbidity of those affected, especially in deficient/insufficient individuals. Obtaining serum 25 (OH) D levels in all patients with viral respiratory infections, especially COVID-19, could help in the detection and treatment of Vitamin D deficiency and potentially decrease recovery time and improve outcome. Even though evidence suggests that vitamin D has the anti-inflammatory, antiviral properties, randomized double-blinded controlled trials are needed to verify this further, and to understand Vitamin D and COVID-19 better. Abbreviations Vitamin D receptor-VDR; 25(OH)D- 25 hydroxyvitamin D; 1,25 (OH)D-1,25 dihydroxy Vitamin D; 1α,25-dihydroxy Vitamin D-1,25[OH]2 D or calcitriol; IU- International Units; Interferons stimulated genes- ISG; ARI- acute respiratory infection; RSV- respiratory syncytial virus; RTI- Respiratory tract infections; COPD-Chronic obstructive pulmonary disease; BMI-Basal metabolic index; USA-USA. |
| first_indexed | 2024-04-11T02:13:52Z |
| format | Article |
| id | doaj.art-47b300cfff2448e0a234481b27ff6b69 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:13:52Z |
| publishDate | 2020-11-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-47b300cfff2448e0a234481b27ff6b692023-01-03T01:29:00ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662020-11-0110652953610.1080/20009666.2020.18110741811074Back to basics: review on vitamin D and respiratory viral infections including COVID-19Mamtha Balla0Ganesh Prasad Merugu1Venu Madhav Konala2Vikram Sangani3Hema Kondakindi4Mytri PokalVijay Gayam5Sreedhar Adapa6Srikanth Naramala7Srikrishna V Malayala8University of Toledo and Promedica Toledo HospitalUniversity of Toledo- Health SciencesAshland Bellefonte Cancer CenterMedical Center of Central GeorgiaDurgabhai Deshmukh Hospital and Research CenterMedical Center of Central GeorgiaInterfaith Medical CenterAdventist Medical CenterAdventist Medical CenterImportance As the scientific community is in a marathon in finding out the cure for COVID-19, in this crisis, it is essential for the physicians not to forget about the basics. Due to the pandemic crisis, in many nursing homes and hospitals, there established new policies on decreasing unnecessary medications to minimize cross-contamination. Sometimes these policies are making providers avoid essential drugs such as Vitamins, including Vitamin D. In this paper, we try to emphasize the importance of Vitamin D in COVID-19 and respiratory viral patients. Relevance Vitamin D helps in decreasing the ‘pro-inflammatory cytokines’ in the lungs and acts in immunomodulatory function, and ‘also it will increase the anti-inflammatory, antiviral responses of the respiratory epithelial cells during infection.’ Conclusion Due to the highly contagious nature of COVID-19 and the increased morbidity and mortality with no appropriate therapy and vaccine, one must be cautious and do everything to help COVID-19 patients. In hospitals and other health care settings to decrease cross-contamination, holding other non-essential medications is taking place. Discontinuing Vitamins could increase the mortality and morbidity of those affected, especially in deficient/insufficient individuals. Obtaining serum 25 (OH) D levels in all patients with viral respiratory infections, especially COVID-19, could help in the detection and treatment of Vitamin D deficiency and potentially decrease recovery time and improve outcome. Even though evidence suggests that vitamin D has the anti-inflammatory, antiviral properties, randomized double-blinded controlled trials are needed to verify this further, and to understand Vitamin D and COVID-19 better. Abbreviations Vitamin D receptor-VDR; 25(OH)D- 25 hydroxyvitamin D; 1,25 (OH)D-1,25 dihydroxy Vitamin D; 1α,25-dihydroxy Vitamin D-1,25[OH]2 D or calcitriol; IU- International Units; Interferons stimulated genes- ISG; ARI- acute respiratory infection; RSV- respiratory syncytial virus; RTI- Respiratory tract infections; COPD-Chronic obstructive pulmonary disease; BMI-Basal metabolic index; USA-USA.http://dx.doi.org/10.1080/20009666.2020.18110741,25(oh)2 dcalcitriolcovid-19sars cov2respiratory tract infectionsrespiratory viruses25(oh) dvitamin d |
| spellingShingle | Mamtha Balla Ganesh Prasad Merugu Venu Madhav Konala Vikram Sangani Hema Kondakindi Mytri Pokal Vijay Gayam Sreedhar Adapa Srikanth Naramala Srikrishna V Malayala Back to basics: review on vitamin D and respiratory viral infections including COVID-19 Journal of Community Hospital Internal Medicine Perspectives 1,25(oh)2 d calcitriol covid-19 sars cov2 respiratory tract infections respiratory viruses 25(oh) d vitamin d |
| title | Back to basics: review on vitamin D and respiratory viral infections including COVID-19 |
| title_full | Back to basics: review on vitamin D and respiratory viral infections including COVID-19 |
| title_fullStr | Back to basics: review on vitamin D and respiratory viral infections including COVID-19 |
| title_full_unstemmed | Back to basics: review on vitamin D and respiratory viral infections including COVID-19 |
| title_short | Back to basics: review on vitamin D and respiratory viral infections including COVID-19 |
| title_sort | back to basics review on vitamin d and respiratory viral infections including covid 19 |
| topic | 1,25(oh)2 d calcitriol covid-19 sars cov2 respiratory tract infections respiratory viruses 25(oh) d vitamin d |
| url | http://dx.doi.org/10.1080/20009666.2020.1811074 |
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