Gestational diabetes mellitus seems to be associatied with inflammation
The aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like protein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 preg...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2015-01-01
|
| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | http://hrcak.srce.hr/file/229170 |
| _version_ | 1828553027027468288 |
|---|---|
| author | Ayla Aktulay Yaprak Engin-Ustun Mehmet Sahin Ozkan Salim Erkaya Mustafa Kara Oktay Kaymak Nuri Danisman |
| author_facet | Ayla Aktulay Yaprak Engin-Ustun Mehmet Sahin Ozkan Salim Erkaya Mustafa Kara Oktay Kaymak Nuri Danisman |
| author_sort | Ayla Aktulay |
| collection | DOAJ |
| description | The aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like protein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 pregnant women with GDM and 29 pregnant women with normal glucose tolerance matched for age (±2 years) and pre-pregnancy body mass index (±2 kg/m2). The
YKL-40/CHI3L1 levels were measured, and NLR and PLR investigated. There were no statistically significant differences in maternal age, gestational age, gravidity and parity. Higher YKL-40 levels were recorded in pregnant women with GDM compared to control subjects (203 (65-300) ng/mL vs. 159.2 (14-290) ng/mL, p=0.007). NLR and PLR were significantly higher in GDM compared with control group. In conclusion, GDM is associated with high levels of YKL-40, NLR and PLR, which indicate inflammatory status. |
| first_indexed | 2024-12-12T05:11:39Z |
| format | Article |
| id | doaj.art-47b3f96c8ccc4103b8d1cbbe3fb77071 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-12-12T05:11:39Z |
| publishDate | 2015-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-47b3f96c8ccc4103b8d1cbbe3fb770712022-12-22T00:36:54ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512015-01-0154.4.475478Gestational diabetes mellitus seems to be associatied with inflammationAyla Aktulay0Yaprak Engin-Ustun1Mehmet Sahin Ozkan2Salim Erkaya3Mustafa Kara4Oktay Kaymak5Nuri Danisman6Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, TurkeyDepartment of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, TurkeyDepartment of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, TurkeyDepartment of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, TurkeyDepartment of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, TurkeyDepartment of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, TurkeyDepartment of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, TurkeyThe aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like protein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 pregnant women with GDM and 29 pregnant women with normal glucose tolerance matched for age (±2 years) and pre-pregnancy body mass index (±2 kg/m2). The YKL-40/CHI3L1 levels were measured, and NLR and PLR investigated. There were no statistically significant differences in maternal age, gestational age, gravidity and parity. Higher YKL-40 levels were recorded in pregnant women with GDM compared to control subjects (203 (65-300) ng/mL vs. 159.2 (14-290) ng/mL, p=0.007). NLR and PLR were significantly higher in GDM compared with control group. In conclusion, GDM is associated with high levels of YKL-40, NLR and PLR, which indicate inflammatory status.http://hrcak.srce.hr/file/229170CHI3L1 protein, humanDiabetes, gestationalLeukocyte countNeutrophils – cytologyLymphocytes – cytologyBlood platelets – cytology |
| spellingShingle | Ayla Aktulay Yaprak Engin-Ustun Mehmet Sahin Ozkan Salim Erkaya Mustafa Kara Oktay Kaymak Nuri Danisman Gestational diabetes mellitus seems to be associatied with inflammation Acta Clinica Croatica CHI3L1 protein, human Diabetes, gestational Leukocyte count Neutrophils – cytology Lymphocytes – cytology Blood platelets – cytology |
| title | Gestational diabetes mellitus seems to be associatied with inflammation |
| title_full | Gestational diabetes mellitus seems to be associatied with inflammation |
| title_fullStr | Gestational diabetes mellitus seems to be associatied with inflammation |
| title_full_unstemmed | Gestational diabetes mellitus seems to be associatied with inflammation |
| title_short | Gestational diabetes mellitus seems to be associatied with inflammation |
| title_sort | gestational diabetes mellitus seems to be associatied with inflammation |
| topic | CHI3L1 protein, human Diabetes, gestational Leukocyte count Neutrophils – cytology Lymphocytes – cytology Blood platelets – cytology |
| url | http://hrcak.srce.hr/file/229170 |
| work_keys_str_mv | AT aylaaktulay gestationaldiabetesmellitusseemstobeassociatiedwithinflammation AT yaprakenginustun gestationaldiabetesmellitusseemstobeassociatiedwithinflammation AT mehmetsahinozkan gestationaldiabetesmellitusseemstobeassociatiedwithinflammation AT salimerkaya gestationaldiabetesmellitusseemstobeassociatiedwithinflammation AT mustafakara gestationaldiabetesmellitusseemstobeassociatiedwithinflammation AT oktaykaymak gestationaldiabetesmellitusseemstobeassociatiedwithinflammation AT nuridanisman gestationaldiabetesmellitusseemstobeassociatiedwithinflammation |