The Role of Androgen Receptor Signaling in Ovarian Cancer
Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor progression. However, conflicting findings ha...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/8/2/176 |
| _version_ | 1797725328206987264 |
|---|---|
| author | Taichi Mizushima Hiroshi Miyamoto |
| author_facet | Taichi Mizushima Hiroshi Miyamoto |
| author_sort | Taichi Mizushima |
| collection | DOAJ |
| description | Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor progression. However, conflicting findings have also been reported. This review summarizes and discusses the available data indicating the involvement of androgens as well as androgen receptor and related signals in ovarian carcinogenesis and cancer growth. Although the underlying molecular mechanisms for androgen receptor functions in ovarian cancer remain far from being fully understood, current observations may offer effective chemopreventive and therapeutic approaches, via modulation of androgen receptor activity, against ovarian cancer. Indeed, several clinical trials have been conducted to determine the efficacy of androgen deprivation therapy in patients with ovarian cancer. |
| first_indexed | 2024-03-12T10:29:36Z |
| format | Article |
| id | doaj.art-47b40196bd074e11ba585cb5b30f11cf |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T10:29:36Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-47b40196bd074e11ba585cb5b30f11cf2023-09-02T09:23:12ZengMDPI AGCells2073-44092019-02-018217610.3390/cells8020176cells8020176The Role of Androgen Receptor Signaling in Ovarian CancerTaichi Mizushima0Hiroshi Miyamoto1Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USADepartment of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USAEmerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor progression. However, conflicting findings have also been reported. This review summarizes and discusses the available data indicating the involvement of androgens as well as androgen receptor and related signals in ovarian carcinogenesis and cancer growth. Although the underlying molecular mechanisms for androgen receptor functions in ovarian cancer remain far from being fully understood, current observations may offer effective chemopreventive and therapeutic approaches, via modulation of androgen receptor activity, against ovarian cancer. Indeed, several clinical trials have been conducted to determine the efficacy of androgen deprivation therapy in patients with ovarian cancer.https://www.mdpi.com/2073-4409/8/2/176androgenandrogen receptorcarcinogenesisovarytumor progression |
| spellingShingle | Taichi Mizushima Hiroshi Miyamoto The Role of Androgen Receptor Signaling in Ovarian Cancer Cells androgen androgen receptor carcinogenesis ovary tumor progression |
| title | The Role of Androgen Receptor Signaling in Ovarian Cancer |
| title_full | The Role of Androgen Receptor Signaling in Ovarian Cancer |
| title_fullStr | The Role of Androgen Receptor Signaling in Ovarian Cancer |
| title_full_unstemmed | The Role of Androgen Receptor Signaling in Ovarian Cancer |
| title_short | The Role of Androgen Receptor Signaling in Ovarian Cancer |
| title_sort | role of androgen receptor signaling in ovarian cancer |
| topic | androgen androgen receptor carcinogenesis ovary tumor progression |
| url | https://www.mdpi.com/2073-4409/8/2/176 |
| work_keys_str_mv | AT taichimizushima theroleofandrogenreceptorsignalinginovariancancer AT hiroshimiyamoto theroleofandrogenreceptorsignalinginovariancancer AT taichimizushima roleofandrogenreceptorsignalinginovariancancer AT hiroshimiyamoto roleofandrogenreceptorsignalinginovariancancer |