Enantioselective metabolism of hydroxychloroquine employing rats and mice hepatic microsomes

Enantioselective metabolism of hydroxychloroquine employing rats and mice hepatic microsomes

Hydroxychloroquine (HCQ) is an important chiral drug used, mainly, in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria, and whose pharmacokinetic and pharmacodynamic properties look to be stereoselective. Respecting the pharmacokinetic properties, some previous studies...

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Bibliographic Details
Main Authors:	Carmem Dickow Cardoso, Pierina Sueli Bonato
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2009-12-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Hidroxicloroquina Metabolismo estereosseletivo Cromatografia líquida de alta eficiência Eletroforese capilar Hydroxychloroquine Stereoselective metabolism High performance liquid chromatography Capillary electrophoresis
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400008

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