Changes in Dickkopf-1, but Not Sclerostin, in Gingival Crevicular Fluid Are Associated with Peroral Statin Treatment in Patients with Periodontitis

Changes in Dickkopf-1, but Not Sclerostin, in Gingival Crevicular Fluid Are Associated with Peroral Statin Treatment in Patients with Periodontitis

<i>Background and Objectives</i>: Periodontitis is marked by the destruction of alveolar bone. Sclerostin (SOST) and dickkopf-1 (DKK-1) act as inhibitors of the Wingless-type (Wnt) signaling pathway, a key regulator of bone metabolism. Recent studies have suggested that statins play a ro...

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Bibliographic Details
Main Authors: Kristina Duspara, Renata Sikora, Ana Petrovic, Lucija Kuna Roguljic, Anita Matic, Kristina Kralik, Hrvoje Roguljic, Tomislav Kizivat, Mirjana Duspara, Dunja Igrec, Kristina Bojanic, Robert Smolic, Aleksandar Vcev, Magdalena Wyszyńska, George Y. Wu, Martina Smolic
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Medicina
Subjects:
DKK-1
GCF
periodontitis
sclerostin
statins
Wnt signaling pathway
Online Access:https://www.mdpi.com/1648-9144/60/3/508

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