Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment

Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment

Niclosamide (NIC), a conventional anthelmintic agent, is emerging as a repurposed drug for COVID-19 treatment. However, the clinical efficacy is very limited due to its low oral bioavailability resulting from its poor aqueous solubility. In the present study, a new hybrid drug delivery system made o...

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Bibliographic Details
Main Authors: Seungjin Yu, Huiyan Piao, N. Sanoj Rejinold, Geunwoo Jin, Goeun Choi, Jin-Ho Choy
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Polymers
Subjects:
niclosamide
poorly-soluble drug
montmorillonite
Tween 60
drug delivery
solubility enhancement
Online Access:https://www.mdpi.com/2073-4360/13/7/1044

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