The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis
Abstract Background Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the metabolism of tryptophan into kynurenine. It is considered to be an immunosuppressive molecule that plays an important role in the development of tumors. However, the association between IDO and solid tumor progno...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-020-06956-5 |
| _version_ | 1818579705837649920 |
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| author | Sen Wang Jia Wu Han Shen Junjun Wang |
| author_facet | Sen Wang Jia Wu Han Shen Junjun Wang |
| author_sort | Sen Wang |
| collection | DOAJ |
| description | Abstract Background Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the metabolism of tryptophan into kynurenine. It is considered to be an immunosuppressive molecule that plays an important role in the development of tumors. However, the association between IDO and solid tumor prognosis remains unclear. Herein, we retrieved relevant published literature and analyzed the association between IDO expression and prognosis in solid tumors. Methods Studies related to IDO expression and tumor prognosis were retrieved using PMC, EMbase and web of science database. Overall survival (OS), time to tumor progression (TTP) and other data in each study were extracted. Hazard ratio (HR) was used for analysis and calculation, while heterogeneity and publication bias between studies were also analyzed. Results A total of 31 studies were included in this meta-analysis. Overall, high expression of IDO was significantly associated with poor OS (HR 1.92, 95% CI 1.52–2.43, P < 0.001) and TTP (HR 2.25 95% CI 1.58–3.22, P < 0.001). However, there was significant heterogeneity between studies on OS (I2 = 81.1%, P < 0.001) and TTP (I2 = 54.8%, P = 0.007). Subgroup analysis showed lower heterogeneity among prospective studies, studies of the same tumor type, and studies with follow-up periods longer than 45 months. Conclusions The high expression of IDO was significantly associated with the poor prognosis of solid tumors, suggesting that it can be used as a biomarker for tumor prognosis and as a potential target for tumor therapy. |
| first_indexed | 2024-12-16T07:05:57Z |
| format | Article |
| id | doaj.art-47b8177ce98444cdbda34c579444d53c |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-16T07:05:57Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-47b8177ce98444cdbda34c579444d53c2022-12-21T22:40:02ZengBMCBMC Cancer1471-24072020-05-0120111110.1186/s12885-020-06956-5The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysisSen Wang0Jia Wu1Han Shen2Junjun Wang3Department of Clinical Laboratory Medicine, Jinling Hospital, Medical School of Nanjing UniversityDepartment of Clinical Laboratory Medicine, Jinling Hospital, Medical School of Nanjing UniversityDepartment of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital, Medical School of Nanjing UniversityDepartment of Clinical Laboratory Medicine, Jinling Hospital, Medical School of Nanjing UniversityAbstract Background Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the metabolism of tryptophan into kynurenine. It is considered to be an immunosuppressive molecule that plays an important role in the development of tumors. However, the association between IDO and solid tumor prognosis remains unclear. Herein, we retrieved relevant published literature and analyzed the association between IDO expression and prognosis in solid tumors. Methods Studies related to IDO expression and tumor prognosis were retrieved using PMC, EMbase and web of science database. Overall survival (OS), time to tumor progression (TTP) and other data in each study were extracted. Hazard ratio (HR) was used for analysis and calculation, while heterogeneity and publication bias between studies were also analyzed. Results A total of 31 studies were included in this meta-analysis. Overall, high expression of IDO was significantly associated with poor OS (HR 1.92, 95% CI 1.52–2.43, P < 0.001) and TTP (HR 2.25 95% CI 1.58–3.22, P < 0.001). However, there was significant heterogeneity between studies on OS (I2 = 81.1%, P < 0.001) and TTP (I2 = 54.8%, P = 0.007). Subgroup analysis showed lower heterogeneity among prospective studies, studies of the same tumor type, and studies with follow-up periods longer than 45 months. Conclusions The high expression of IDO was significantly associated with the poor prognosis of solid tumors, suggesting that it can be used as a biomarker for tumor prognosis and as a potential target for tumor therapy.http://link.springer.com/article/10.1186/s12885-020-06956-5Meta-analysisIDOSolid tumorSurvival |
| spellingShingle | Sen Wang Jia Wu Han Shen Junjun Wang The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis BMC Cancer Meta-analysis IDO Solid tumor Survival |
| title | The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis |
| title_full | The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis |
| title_fullStr | The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis |
| title_full_unstemmed | The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis |
| title_short | The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis |
| title_sort | prognostic value of ido expression in solid tumors a systematic review and meta analysis |
| topic | Meta-analysis IDO Solid tumor Survival |
| url | http://link.springer.com/article/10.1186/s12885-020-06956-5 |
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