Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge
The COVID-19 pandemic has impacted every country in the world. With more than 400 million cases and more than 5.5 million deaths. The FDA either approved or authorized the emergency use for three vaccines against COVID-19. The treatment options of COVID-19 are very limited. Multiple complementary an...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.848676/full |
| _version_ | 1811313217442414592 |
|---|---|
| author | Maen Abdelrahim Maen Abdelrahim Maen Abdelrahim Abdullah Esmail Abdullah Esmail Abdullah Esmail Noor Al Saadi Eva Zsigmond Ebtesam Al Najjar Doaa Bugazia Hadeel Al-Rawi Ayat Alsaadi Ahmed O. Kaseb |
| author_facet | Maen Abdelrahim Maen Abdelrahim Maen Abdelrahim Abdullah Esmail Abdullah Esmail Abdullah Esmail Noor Al Saadi Eva Zsigmond Ebtesam Al Najjar Doaa Bugazia Hadeel Al-Rawi Ayat Alsaadi Ahmed O. Kaseb |
| author_sort | Maen Abdelrahim |
| collection | DOAJ |
| description | The COVID-19 pandemic has impacted every country in the world. With more than 400 million cases and more than 5.5 million deaths. The FDA either approved or authorized the emergency use for three vaccines against COVID-19. The treatment options of COVID-19 are very limited. Multiple complementary and alternative medicine modalities were suggested to be efficacious in the treatment of COVID-19 such as Thymoquinone. The effects of Thymoquinone have been examined and multiple studies indicate a promising beneficial effect. However, the current body of research is limited in terms of its scope, quality, and quantity. While higher-quality studies are required, physicians do not routinely recommend the use of marketed supplements of natural products, including Thymoquinone for COVID-19. Given the numerous suggested positive effects of Thymoquinone, including anti-inflammatory and antimicrobial properties, additional research is required to confirm or refute these promising benefits. Complementary and alternative medicine is an area that requires additional evidence-based practice and research to confirm effects observed in clinical practice. |
| first_indexed | 2024-04-13T10:49:57Z |
| format | Article |
| id | doaj.art-47b946686a72463d82f4fdc40722f132 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T10:49:57Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-47b946686a72463d82f4fdc40722f1322022-12-22T02:49:41ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-04-011310.3389/fphar.2022.848676848676Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant SurgeMaen Abdelrahim0Maen Abdelrahim1Maen Abdelrahim2Abdullah Esmail3Abdullah Esmail4Abdullah Esmail5Noor Al Saadi6Eva Zsigmond7Ebtesam Al Najjar8Doaa Bugazia9Hadeel Al-Rawi10Ayat Alsaadi11Ahmed O. Kaseb12Houston Methodist Cancer Center, Houston Methodist Hospital, Houston, TX, United StatesCockrell Center for Advanced Therapeutic Phase I Program, Houston Methodist Research Institute, Houston, TX, United StatesWeill Cornell Medical College, Institute of Academic Medicine, Houston, TX, United StatesHouston Methodist Cancer Center, Houston Methodist Hospital, Houston, TX, United StatesHouston Methodist Research Institute, Houston, TX, United StatesFaculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, YemenFaculty of Medicine, Xavier University School of Medicine Aruba, Oranjestad, ArubaHouston Methodist Cancer Center, Houston Methodist Hospital, Houston, TX, United StatesFaculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, YemenFaculty of Medicine, University of Tripoli, Tripoli, LibyaFaculty of Medicine, University of Jordan, Amman, JordanDepartment of Biology and Chemistry, Buffalo State College, Buffalo, NY, United States0Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesThe COVID-19 pandemic has impacted every country in the world. With more than 400 million cases and more than 5.5 million deaths. The FDA either approved or authorized the emergency use for three vaccines against COVID-19. The treatment options of COVID-19 are very limited. Multiple complementary and alternative medicine modalities were suggested to be efficacious in the treatment of COVID-19 such as Thymoquinone. The effects of Thymoquinone have been examined and multiple studies indicate a promising beneficial effect. However, the current body of research is limited in terms of its scope, quality, and quantity. While higher-quality studies are required, physicians do not routinely recommend the use of marketed supplements of natural products, including Thymoquinone for COVID-19. Given the numerous suggested positive effects of Thymoquinone, including anti-inflammatory and antimicrobial properties, additional research is required to confirm or refute these promising benefits. Complementary and alternative medicine is an area that requires additional evidence-based practice and research to confirm effects observed in clinical practice.https://www.frontiersin.org/articles/10.3389/fphar.2022.848676/fullCOVID-19pandemicCoronavirusThymoquinonePAXLOVIDmolnupiravir |
| spellingShingle | Maen Abdelrahim Maen Abdelrahim Maen Abdelrahim Abdullah Esmail Abdullah Esmail Abdullah Esmail Noor Al Saadi Eva Zsigmond Ebtesam Al Najjar Doaa Bugazia Hadeel Al-Rawi Ayat Alsaadi Ahmed O. Kaseb Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge Frontiers in Pharmacology COVID-19 pandemic Coronavirus Thymoquinone PAXLOVID molnupiravir |
| title | Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge |
| title_full | Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge |
| title_fullStr | Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge |
| title_full_unstemmed | Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge |
| title_short | Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge |
| title_sort | thymoquinone s antiviral effects it is time to be proven in the covid 19 pandemic era and its omicron variant surge |
| topic | COVID-19 pandemic Coronavirus Thymoquinone PAXLOVID molnupiravir |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.848676/full |
| work_keys_str_mv | AT maenabdelrahim thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT maenabdelrahim thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT maenabdelrahim thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT abdullahesmail thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT abdullahesmail thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT abdullahesmail thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT nooralsaadi thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT evazsigmond thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT ebtesamalnajjar thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT doaabugazia thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT hadeelalrawi thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT ayatalsaadi thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge AT ahmedokaseb thymoquinonesantiviraleffectsitistimetobeproveninthecovid19pandemiceraanditsomicronvariantsurge |