COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies
AbstractAim Kidney transplant recipients (KTRs), due to their immunosuppressed status, are potentially more susceptible to both the severe effects of COVID-19 and complications in their transplanted organ. The aim of this study is to investigate whether COVID-19 infection increases the risk of rejec...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2336126 |
| _version_ | 1797203424568147968 |
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| author | Ahmed Daoud Karim Soliman Maria Aurora Posadas Salas Genta Uehara Sakshi Vaishnav Wisit Cheungpasitporn Michael J. Casey |
| author_facet | Ahmed Daoud Karim Soliman Maria Aurora Posadas Salas Genta Uehara Sakshi Vaishnav Wisit Cheungpasitporn Michael J. Casey |
| author_sort | Ahmed Daoud |
| collection | DOAJ |
| description | AbstractAim Kidney transplant recipients (KTRs), due to their immunosuppressed status, are potentially more susceptible to both the severe effects of COVID-19 and complications in their transplanted organ. The aim of this study is to investigate whether COVID-19 infection increases the risk of rejection in kidney transplant recipients (KTRs).Methods This study involved a detailed literature review, conducted using PubMed, with the search being completed by September 7th, 2023. The search strategy incorporated a combination of relevant keywords: ‘COVID’, ‘Renal’, ‘Kidney’, ‘Transplant’, and ‘Rejection’. The results from controlled and uncontrolled studies were separately collated and analyzed.Results A total of 11 studies were identified, encompassing 1,179 patients. Among these, two controlled studies reported the incidence of rejection in KTRs infected with COVID-19. Pooling data from these studies revealed no significant statistical correlation between COVID-19 infection and biopsy-proven rejection (p = 0.26). In addition, nine non-controlled studies were found, with rejection incidences ranging from 0% to 66.7%. The majority of these studies (eight out of nine) had small sample sizes, ranging from 3 to 75 KTRs, while the largest included 372 KTRs. The combined rejection rate across these studies was calculated to be 11.8%.Conclusion In conclusion, the limited number of published controlled studies revealed no statistically significant association between COVID-19 infection and biopsy-proven rejection among KTRs. However, the broader analysis of non-controlled studies showed a variable rejection incidence with a pooled rejection rate of 11.8%. There is insufficient high-quality data to explore the association of COVID-19 infection and rejection. |
| first_indexed | 2024-04-24T08:19:07Z |
| format | Article |
| id | doaj.art-47bc1f9ff20542488ca22b28f5ea08b8 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T08:19:07Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-47bc1f9ff20542488ca22b28f5ea08b82024-04-17T02:19:43ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2336126COVID-19 and renal allograft rejection: insight from controlled and non-controlled studiesAhmed Daoud0Karim Soliman1Maria Aurora Posadas Salas2Genta Uehara3Sakshi Vaishnav4Wisit Cheungpasitporn5Michael J. Casey6Medical University of South Carolina, Charleston, SC, USAMedical University of South Carolina, Charleston, SC, USAMedical University of South Carolina, Charleston, SC, USAMedical University of South Carolina, Charleston, SC, USAMedical University of South Carolina, Charleston, SC, USADivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USAMedical University of South Carolina, Charleston, SC, USAAbstractAim Kidney transplant recipients (KTRs), due to their immunosuppressed status, are potentially more susceptible to both the severe effects of COVID-19 and complications in their transplanted organ. The aim of this study is to investigate whether COVID-19 infection increases the risk of rejection in kidney transplant recipients (KTRs).Methods This study involved a detailed literature review, conducted using PubMed, with the search being completed by September 7th, 2023. The search strategy incorporated a combination of relevant keywords: ‘COVID’, ‘Renal’, ‘Kidney’, ‘Transplant’, and ‘Rejection’. The results from controlled and uncontrolled studies were separately collated and analyzed.Results A total of 11 studies were identified, encompassing 1,179 patients. Among these, two controlled studies reported the incidence of rejection in KTRs infected with COVID-19. Pooling data from these studies revealed no significant statistical correlation between COVID-19 infection and biopsy-proven rejection (p = 0.26). In addition, nine non-controlled studies were found, with rejection incidences ranging from 0% to 66.7%. The majority of these studies (eight out of nine) had small sample sizes, ranging from 3 to 75 KTRs, while the largest included 372 KTRs. The combined rejection rate across these studies was calculated to be 11.8%.Conclusion In conclusion, the limited number of published controlled studies revealed no statistically significant association between COVID-19 infection and biopsy-proven rejection among KTRs. However, the broader analysis of non-controlled studies showed a variable rejection incidence with a pooled rejection rate of 11.8%. There is insufficient high-quality data to explore the association of COVID-19 infection and rejection.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2336126COVIDrenalkidneytransplantrejection |
| spellingShingle | Ahmed Daoud Karim Soliman Maria Aurora Posadas Salas Genta Uehara Sakshi Vaishnav Wisit Cheungpasitporn Michael J. Casey COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies Renal Failure COVID renal kidney transplant rejection |
| title | COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies |
| title_full | COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies |
| title_fullStr | COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies |
| title_full_unstemmed | COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies |
| title_short | COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies |
| title_sort | covid 19 and renal allograft rejection insight from controlled and non controlled studies |
| topic | COVID renal kidney transplant rejection |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2336126 |
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