Glycines from the APP GXXXG/GXXXA transmembrane motifs promote formation of pathogenic Aβ oligomers in cells

Glycines from the APP GXXXG/GXXXA transmembrane motifs promote formation of pathogenic Aβ oligomers in cells

Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by progressive cognitive decline leading to dementia. The amyloid precursor protein (APP) is a ubiquitous type I transmembrane (TM) protein sequentially processed to generate the β-amyloid peptide (Aβ), the major co...

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Bibliographic Details
Main Authors: Marie eDecock, Serena eStanga, Jean-Noël eOctave, Ilse eDewachter, Steven O Smith, Stefan N Constantinescu, Pascal eKienlen-Campard
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
oligomers
Alzheimer’s disease
amyloid precursor protein
neuronal differentiation
Beta-amyloid peptide
GXXXG motifs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00107/full

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