Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis
Oxidative stress plays an important role in the onset as well as the progression of inflammation. Without proper intervention, acute inflammation could progress to chronic inflammation, resulting in the development of inflammatory diseases. Antioxidants, such as polyphenols, have been known to posse...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/9/8/669 |
| _version_ | 1797561296692969472 |
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| author | Amritpal Singh Yu Fung Yau Kin Sum Leung Hani El-Nezami Jetty Chung-Yung Lee |
| author_facet | Amritpal Singh Yu Fung Yau Kin Sum Leung Hani El-Nezami Jetty Chung-Yung Lee |
| author_sort | Amritpal Singh |
| collection | DOAJ |
| description | Oxidative stress plays an important role in the onset as well as the progression of inflammation. Without proper intervention, acute inflammation could progress to chronic inflammation, resulting in the development of inflammatory diseases. Antioxidants, such as polyphenols, have been known to possess anti-oxidative properties which promote redox homeostasis. This has encouraged research on polyphenols as potential therapeutics for inflammation through anti-oxidative and anti-inflammatory pathways. In this review, the ability of polyphenols to modulate the activation of major pathways of inflammation and oxidative stress, and their potential to regulate the activity of immune cells are examined. In addition, in this review, special emphasis has been placed on the effects of polyphenols on inflammation in the brain–liver–gut axis. The data derived from in vitro cell studies, animal models and human intervention studies are discussed. |
| first_indexed | 2024-03-10T18:11:54Z |
| format | Article |
| id | doaj.art-47bccf1ce8214116ad78c41b2aac2d7c |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T18:11:54Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-47bccf1ce8214116ad78c41b2aac2d7c2023-11-20T08:01:16ZengMDPI AGAntioxidants2076-39212020-07-019866910.3390/antiox9080669Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut AxisAmritpal Singh0Yu Fung Yau1Kin Sum Leung2Hani El-Nezami3Jetty Chung-Yung Lee4School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, ChinaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, ChinaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, ChinaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, ChinaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, ChinaOxidative stress plays an important role in the onset as well as the progression of inflammation. Without proper intervention, acute inflammation could progress to chronic inflammation, resulting in the development of inflammatory diseases. Antioxidants, such as polyphenols, have been known to possess anti-oxidative properties which promote redox homeostasis. This has encouraged research on polyphenols as potential therapeutics for inflammation through anti-oxidative and anti-inflammatory pathways. In this review, the ability of polyphenols to modulate the activation of major pathways of inflammation and oxidative stress, and their potential to regulate the activity of immune cells are examined. In addition, in this review, special emphasis has been placed on the effects of polyphenols on inflammation in the brain–liver–gut axis. The data derived from in vitro cell studies, animal models and human intervention studies are discussed.https://www.mdpi.com/2076-3921/9/8/669oxidative stressinflammationpolyphenolsantioxidant |
| spellingShingle | Amritpal Singh Yu Fung Yau Kin Sum Leung Hani El-Nezami Jetty Chung-Yung Lee Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis Antioxidants oxidative stress inflammation polyphenols antioxidant |
| title | Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis |
| title_full | Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis |
| title_fullStr | Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis |
| title_full_unstemmed | Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis |
| title_short | Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis |
| title_sort | interaction of polyphenols as antioxidant and anti inflammatory compounds in brain liver gut axis |
| topic | oxidative stress inflammation polyphenols antioxidant |
| url | https://www.mdpi.com/2076-3921/9/8/669 |
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