Epidermal Growth Factor Receptor Inhibition Reverses Cellular and Transcriptomic Alterations Induced by Hypoxia in the Neonatal Piglet Brain

Epidermal Growth Factor Receptor Inhibition Reverses Cellular and Transcriptomic Alterations Induced by Hypoxia in the Neonatal Piglet Brain

Summary: Acute hypoxia (HX) causes extensive cellular damage in the developing human cerebral cortex. We found increased expression of activated-EGFR in affected cortical areas of neonates with HX and investigated its functional role in the piglet, which displays a highly evolved, gyrencephalic brai...

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Bibliographic Details
Main Authors: Panagiotis Kratimenos, Evan Z. Goldstein, Ioannis Koutroulis, Susan Knoblach, Beata Jablonska, Payal Banerjee, Shadi N. Malaeb, Surajit Bhattacharya, M. Isabel Almira-Suarez, Vittorio Gallo, Maria Delivoria-Papadopoulos
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Porcine Molecular Biology
Developmental Neuroscience
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309639

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