Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative Pain
Safe and non-invasive on-demand relief is a crucial and effective treatment for postoperative pain because it considers variable timing and intensity of anesthetics. Ultrasound modulation is a promising technique for this treatment because it allows convenient timed and non-invasive controlled drug...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.925047/full |
| _version_ | 1811324306252103680 |
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| author | Xiaohong Chen Xiaohong Chen Jianfeng Zhang Yan Yu Haoran Wang Genshan Ma Di Wang Hanzhong Cao Jianping Yang |
| author_facet | Xiaohong Chen Xiaohong Chen Jianfeng Zhang Yan Yu Haoran Wang Genshan Ma Di Wang Hanzhong Cao Jianping Yang |
| author_sort | Xiaohong Chen |
| collection | DOAJ |
| description | Safe and non-invasive on-demand relief is a crucial and effective treatment for postoperative pain because it considers variable timing and intensity of anesthetics. Ultrasound modulation is a promising technique for this treatment because it allows convenient timed and non-invasive controlled drug release. Here, we created an ultrasound-triggered lidocaine (Lido) release platform using an amino acid hydrogel functioning as three-dimensional (3D) scaffold material (Lido-PPIX@ER hydrogel). It allows control of the timing, intensity and duration of lidocaine (Lido) to relieve postoperative pain. The hydrogel releases Lido due to the elevated reactive oxygen species (ROS) levels generated by PPIX under ultrasound triggering. The Lido-PPIX@ER hydrogel under individualized ultrasound triggering released lidocaine and provided effective analgesia for more than 72 h. The withdrawal threshold was higher than that in the control group at all time points measured. The hydrogel showed repeatable and adjustable ultrasound-triggered nerve blocks in vivo, the duration of which depended on the extent and intensity of insonation. On histopathology, no systemic effect or tissue reaction was observed in the ultrasound-triggered Lido-PPIX@ER hydrogel-treated group. The Lido-PPIX@ER hydrogel with individualized (highly variable) ultrasound triggering is a convenient and effective method that offers timed and spatiotemporally controlled Lido release to manage postoperative pain. This article presents the delivery system for a new effective strategy to reduce pain, remotely control pain, and offer timed and spatiotemporally controlled release of Lido to manage postoperative pain. |
| first_indexed | 2024-04-13T14:12:02Z |
| format | Article |
| id | doaj.art-47bf533fcc514123a9f28b0f7c1241ad |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T14:12:02Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-47bf533fcc514123a9f28b0f7c1241ad2022-12-22T02:43:46ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-07-011010.3389/fbioe.2022.925047925047Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative PainXiaohong Chen0Xiaohong Chen1Jianfeng Zhang2Yan Yu3Haoran Wang4Genshan Ma5Di Wang6Hanzhong Cao7Jianping Yang8The Frist Affiliated Hospital of Soochow University, Suzhou, ChinaNantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaNantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaNantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaNantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaNantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaNantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaNantong Tumor Hospital, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaThe Frist Affiliated Hospital of Soochow University, Suzhou, ChinaSafe and non-invasive on-demand relief is a crucial and effective treatment for postoperative pain because it considers variable timing and intensity of anesthetics. Ultrasound modulation is a promising technique for this treatment because it allows convenient timed and non-invasive controlled drug release. Here, we created an ultrasound-triggered lidocaine (Lido) release platform using an amino acid hydrogel functioning as three-dimensional (3D) scaffold material (Lido-PPIX@ER hydrogel). It allows control of the timing, intensity and duration of lidocaine (Lido) to relieve postoperative pain. The hydrogel releases Lido due to the elevated reactive oxygen species (ROS) levels generated by PPIX under ultrasound triggering. The Lido-PPIX@ER hydrogel under individualized ultrasound triggering released lidocaine and provided effective analgesia for more than 72 h. The withdrawal threshold was higher than that in the control group at all time points measured. The hydrogel showed repeatable and adjustable ultrasound-triggered nerve blocks in vivo, the duration of which depended on the extent and intensity of insonation. On histopathology, no systemic effect or tissue reaction was observed in the ultrasound-triggered Lido-PPIX@ER hydrogel-treated group. The Lido-PPIX@ER hydrogel with individualized (highly variable) ultrasound triggering is a convenient and effective method that offers timed and spatiotemporally controlled Lido release to manage postoperative pain. This article presents the delivery system for a new effective strategy to reduce pain, remotely control pain, and offer timed and spatiotemporally controlled release of Lido to manage postoperative pain.https://www.frontiersin.org/articles/10.3389/fbioe.2022.925047/fullultrasound-triggered drug releasepostoperative painlidocaineon-demand releaseerythrocytes |
| spellingShingle | Xiaohong Chen Xiaohong Chen Jianfeng Zhang Yan Yu Haoran Wang Genshan Ma Di Wang Hanzhong Cao Jianping Yang Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative Pain Frontiers in Bioengineering and Biotechnology ultrasound-triggered drug release postoperative pain lidocaine on-demand release erythrocytes |
| title | Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative Pain |
| title_full | Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative Pain |
| title_fullStr | Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative Pain |
| title_full_unstemmed | Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative Pain |
| title_short | Ultrasound-Triggered on Demand Lidocaine Release Relieves Postoperative Pain |
| title_sort | ultrasound triggered on demand lidocaine release relieves postoperative pain |
| topic | ultrasound-triggered drug release postoperative pain lidocaine on-demand release erythrocytes |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.925047/full |
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