Altered interaction of physiological activity and behavior affects risky decision-making in ADHD
BackgroundAdult attention-deficit/hyperactivity disorder (ADHD) is often associated with risky decision-making behavior. However, current research studies are often limited by the ability to adequately reflect daily behavior in a laboratory setting. Over the lifespan impairments in cognitive functio...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1147329/full |
| _version_ | 1827964160570294272 |
|---|---|
| author | Eva Halbe Fabian Kolf Alina Sophie Heger Philippa Hüpen Philippa Hüpen Moritz Bergmann Behrem Aslan Ben J. Harrison Christopher G. Davey Alexandra Philipsen Silke Lux |
| author_facet | Eva Halbe Fabian Kolf Alina Sophie Heger Philippa Hüpen Philippa Hüpen Moritz Bergmann Behrem Aslan Ben J. Harrison Christopher G. Davey Alexandra Philipsen Silke Lux |
| author_sort | Eva Halbe |
| collection | DOAJ |
| description | BackgroundAdult attention-deficit/hyperactivity disorder (ADHD) is often associated with risky decision-making behavior. However, current research studies are often limited by the ability to adequately reflect daily behavior in a laboratory setting. Over the lifespan impairments in cognitive functions appear to improve, whereas affective functions become more severe. We assume that risk behavior in ADHD arises predominantly from deficits in affective processes. This study will therefore aim to investigate whether a dysfunction in affective pathways causes an abnormal risky decision-making (DM) behavior in adult ADHD.MethodsTwenty-eight participants with ADHD and twenty-eight healthy controls completed a battery of questionnaires regarding clinical symptoms, self-assessment of behavior and emotional competence. Furthermore, skin conductance responses were measured during the performance in a modified version of the Balloon Analogue Risk Task. A linear mixed-effects model analysis was used to analyze emotional arousal prior to a decision and after feedback display.ResultsResults showed higher emotional arousal in ADHD participants before decision-making (β = −0.12, SE = 0.05, t = −2.63, p < 0.001) and after feedback display (β = −0.14, SE = 0.05, t = −2.66, p = 0.008). Although risky behavior was greater in HC than in ADHD, we found a significant interaction effect of group and anticipatory skin conductance responses regarding the response behavior (β = 107.17, SE = 41.91, t = 2.56, p = 0.011). Post hoc analyses revealed a positive correlation between anticipatory skin conductance responses and reaction time in HC, whereas this correlation was negative in ADHD. Self-assessment results were in line with the objective measurements.ConclusionWe found altered changes in physiological activity during a risky decision-making task. The results confirm the assumption of an aberrant relationship between bodily response and risky behavior in adult ADHD. However, further research is needed with respect to age and gender when considering physiological activities. |
| first_indexed | 2024-04-09T17:11:19Z |
| format | Article |
| id | doaj.art-47bf63fe5cad467aa42481aa9e5f8572 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-09T17:11:19Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-47bf63fe5cad467aa42481aa9e5f85722023-04-20T05:54:35ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-04-011710.3389/fnhum.2023.11473291147329Altered interaction of physiological activity and behavior affects risky decision-making in ADHDEva Halbe0Fabian Kolf1Alina Sophie Heger2Philippa Hüpen3Philippa Hüpen4Moritz Bergmann5Behrem Aslan6Ben J. Harrison7Christopher G. Davey8Alexandra Philipsen9Silke Lux10Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, Aachen, GermanyJARA–Translational Brain Medicine, Aachen, GermanyDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyDepartment of Psychiatry, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Psychiatry, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyBackgroundAdult attention-deficit/hyperactivity disorder (ADHD) is often associated with risky decision-making behavior. However, current research studies are often limited by the ability to adequately reflect daily behavior in a laboratory setting. Over the lifespan impairments in cognitive functions appear to improve, whereas affective functions become more severe. We assume that risk behavior in ADHD arises predominantly from deficits in affective processes. This study will therefore aim to investigate whether a dysfunction in affective pathways causes an abnormal risky decision-making (DM) behavior in adult ADHD.MethodsTwenty-eight participants with ADHD and twenty-eight healthy controls completed a battery of questionnaires regarding clinical symptoms, self-assessment of behavior and emotional competence. Furthermore, skin conductance responses were measured during the performance in a modified version of the Balloon Analogue Risk Task. A linear mixed-effects model analysis was used to analyze emotional arousal prior to a decision and after feedback display.ResultsResults showed higher emotional arousal in ADHD participants before decision-making (β = −0.12, SE = 0.05, t = −2.63, p < 0.001) and after feedback display (β = −0.14, SE = 0.05, t = −2.66, p = 0.008). Although risky behavior was greater in HC than in ADHD, we found a significant interaction effect of group and anticipatory skin conductance responses regarding the response behavior (β = 107.17, SE = 41.91, t = 2.56, p = 0.011). Post hoc analyses revealed a positive correlation between anticipatory skin conductance responses and reaction time in HC, whereas this correlation was negative in ADHD. Self-assessment results were in line with the objective measurements.ConclusionWe found altered changes in physiological activity during a risky decision-making task. The results confirm the assumption of an aberrant relationship between bodily response and risky behavior in adult ADHD. However, further research is needed with respect to age and gender when considering physiological activities.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1147329/fullattention deficit and hyperactivity disorderrisky decision-making behaviorskin conductance response (SCR)autonomic nervous systemphysiological activityaffective functions |
| spellingShingle | Eva Halbe Fabian Kolf Alina Sophie Heger Philippa Hüpen Philippa Hüpen Moritz Bergmann Behrem Aslan Ben J. Harrison Christopher G. Davey Alexandra Philipsen Silke Lux Altered interaction of physiological activity and behavior affects risky decision-making in ADHD Frontiers in Human Neuroscience attention deficit and hyperactivity disorder risky decision-making behavior skin conductance response (SCR) autonomic nervous system physiological activity affective functions |
| title | Altered interaction of physiological activity and behavior affects risky decision-making in ADHD |
| title_full | Altered interaction of physiological activity and behavior affects risky decision-making in ADHD |
| title_fullStr | Altered interaction of physiological activity and behavior affects risky decision-making in ADHD |
| title_full_unstemmed | Altered interaction of physiological activity and behavior affects risky decision-making in ADHD |
| title_short | Altered interaction of physiological activity and behavior affects risky decision-making in ADHD |
| title_sort | altered interaction of physiological activity and behavior affects risky decision making in adhd |
| topic | attention deficit and hyperactivity disorder risky decision-making behavior skin conductance response (SCR) autonomic nervous system physiological activity affective functions |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1147329/full |
| work_keys_str_mv | AT evahalbe alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT fabiankolf alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT alinasophieheger alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT philippahupen alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT philippahupen alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT moritzbergmann alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT behremaslan alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT benjharrison alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT christophergdavey alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT alexandraphilipsen alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd AT silkelux alteredinteractionofphysiologicalactivityandbehavioraffectsriskydecisionmakinginadhd |