Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activation

Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activation

Introduction. The aim of this study was to investigate whether activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) contributes to the development of aldosterone-induced endothelial dysfunction and treatment with the potent PARP inhibitor 1,5-isoquinolinediol (3 mg/kg/day, i.p.) could...

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Bibliographic Details
Main Authors: Arda Tasatargil, Merih Tekcan, Ciler Celik-Ozenci, Nazli Ece Gungor, Bedriniam Dalkiran
Format: Article
Language:English
Published: SAGE Publications 2009-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320309343655

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