Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational study
Background: Cardiac involvement is common in children with multisystem inflammatory syndrome associated with the COVID-19 pandemic. A majority of children have significantly raised levels of NT pro-BNP, ferritin, D-dimers, and cardiac troponin in addition to high C-reactive protein and procalcitonin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Journal of Pediatric Critical Care |
| Subjects: | |
| Online Access: | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2024;volume=11;issue=1;spage=1;epage=5;aulast=Bagri |
| _version_ | 1797222308792762368 |
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| author | Dhan Raj Bagri Rambabu Sharma Chiranji Lal Meena Manohar Lal Gupta Nishant Gopaal Tanya Sood |
| author_facet | Dhan Raj Bagri Rambabu Sharma Chiranji Lal Meena Manohar Lal Gupta Nishant Gopaal Tanya Sood |
| author_sort | Dhan Raj Bagri |
| collection | DOAJ |
| description | Background: Cardiac involvement is common in children with multisystem inflammatory syndrome associated with the COVID-19 pandemic. A majority of children have significantly raised levels of NT pro-BNP, ferritin, D-dimers, and cardiac troponin in addition to high C-reactive protein and procalcitonin levels. Cardiac involvement may include rhythm disturbance, depressed myocardial function, valvar regurgitation, and/or coronary artery inflammation. This hospital-based prospective study was aimed to evaluate cardiovascular manifestations in cases of multisystem inflammatory syndrome in children (MIS-C).
Subjects and Methods: The current study was a prospective observational study that included 100 children admitted to the pediatric intensive care unit after getting the requisite clearance from the institutional ethics committee; informed written consent of parents was taken before the start of the study.
Results: The mean age of the study participants was 8.9 ± 3.9 years with 62% male children. Ninety-four percentage had MIS-C with KD phenotype while only 6% of kids developed shock. Abnormal electrocardiography (ECG) was found in 41%, pericardial effusion in 16%, left ventricular dysfunction (LVD) in 42%, and coronary lesions found in 30% of patients. Abnormal NT-proBNP (>125 pg/ml) was noted in 90% of children. Abnormal cTnT was seen in 89%, and 91% of children had abnormal BNP. The present study found a mortality of 6%.
Conclusions: MIS-C with KD phenotype is the most common presentation with raised cardiac injury markers. Abnormal ECG LVD and coronary lesions are transient common cardiac abnormalities which get resolved within 3 months of treatment. |
| first_indexed | 2024-04-24T13:19:16Z |
| format | Article |
| id | doaj.art-47c18637297e441dadf0dd681c3c344d |
| institution | Directory Open Access Journal |
| issn | 2349-6592 2455-7099 |
| language | English |
| last_indexed | 2024-04-24T13:19:16Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pediatric Critical Care |
| spelling | doaj.art-47c18637297e441dadf0dd681c3c344d2024-04-04T16:28:53ZengWolters Kluwer Medknow PublicationsJournal of Pediatric Critical Care2349-65922455-70992024-01-011111510.4103/jpcc.jpcc_74_23Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational studyDhan Raj BagriRambabu SharmaChiranji Lal MeenaManohar Lal GuptaNishant GopaalTanya SoodBackground: Cardiac involvement is common in children with multisystem inflammatory syndrome associated with the COVID-19 pandemic. A majority of children have significantly raised levels of NT pro-BNP, ferritin, D-dimers, and cardiac troponin in addition to high C-reactive protein and procalcitonin levels. Cardiac involvement may include rhythm disturbance, depressed myocardial function, valvar regurgitation, and/or coronary artery inflammation. This hospital-based prospective study was aimed to evaluate cardiovascular manifestations in cases of multisystem inflammatory syndrome in children (MIS-C). Subjects and Methods: The current study was a prospective observational study that included 100 children admitted to the pediatric intensive care unit after getting the requisite clearance from the institutional ethics committee; informed written consent of parents was taken before the start of the study. Results: The mean age of the study participants was 8.9 ± 3.9 years with 62% male children. Ninety-four percentage had MIS-C with KD phenotype while only 6% of kids developed shock. Abnormal electrocardiography (ECG) was found in 41%, pericardial effusion in 16%, left ventricular dysfunction (LVD) in 42%, and coronary lesions found in 30% of patients. Abnormal NT-proBNP (>125 pg/ml) was noted in 90% of children. Abnormal cTnT was seen in 89%, and 91% of children had abnormal BNP. The present study found a mortality of 6%. Conclusions: MIS-C with KD phenotype is the most common presentation with raised cardiac injury markers. Abnormal ECG LVD and coronary lesions are transient common cardiac abnormalities which get resolved within 3 months of treatment.http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2024;volume=11;issue=1;spage=1;epage=5;aulast=Bagricardiac involvementchildrencoronary artery dilatationcovid-19pericardial effusionsevere acute respiratory syndrome coronavirus 2 |
| spellingShingle | Dhan Raj Bagri Rambabu Sharma Chiranji Lal Meena Manohar Lal Gupta Nishant Gopaal Tanya Sood Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational study Journal of Pediatric Critical Care cardiac involvement children coronary artery dilatation covid-19 pericardial effusion severe acute respiratory syndrome coronavirus 2 |
| title | Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational study |
| title_full | Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational study |
| title_fullStr | Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational study |
| title_full_unstemmed | Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational study |
| title_short | Acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to COVID-19 infection: A single-center prospective observational study |
| title_sort | acute cardiovascular manifestations with multisystem inflammatory syndrome in children due to covid 19 infection a single center prospective observational study |
| topic | cardiac involvement children coronary artery dilatation covid-19 pericardial effusion severe acute respiratory syndrome coronavirus 2 |
| url | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2024;volume=11;issue=1;spage=1;epage=5;aulast=Bagri |
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