Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling

Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling

It is well established that altered purinergic signaling contributes to vascular dysfunction in type 2 diabetes (T2D). Red blood cells (RBCs) serve as an important pool for circulating ATP and the release of ATP from RBCs in response to physiological stimuli is impaired in T2D. We recently demonstra...

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Bibliographic Details
Main Authors: Ali Mahdi, Yahor Tratsiakovich, John Tengbom, Tong Jiao, Lara Garib, Michael Alvarsson, Jiangning Yang, John Pernow, Zhichao Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
erythrocyte
endothelial dysfunction
diabetes
purinergic receptor
adenosine triphosphate
adenosine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.603226/full

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