Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi
Antibiotic resistance is rapidly increasing, and new anti-infective therapies are urgently needed. In this regard, antimicrobial peptides (AMPs) may represent potential candidates for the treatment of infections caused by multiresistant microorganisms. In this narrative review, we reported the exper...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/40 |
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| author | Giulio Rizzetto Daisy Gambini Andrea Maurizi Matteo Candelora Elisa Molinelli Oscar Cirioni Lucia Brescini Andrea Giacometti Annamaria Offidani Oriana Simonetti |
| author_facet | Giulio Rizzetto Daisy Gambini Andrea Maurizi Matteo Candelora Elisa Molinelli Oscar Cirioni Lucia Brescini Andrea Giacometti Annamaria Offidani Oriana Simonetti |
| author_sort | Giulio Rizzetto |
| collection | DOAJ |
| description | Antibiotic resistance is rapidly increasing, and new anti-infective therapies are urgently needed. In this regard, antimicrobial peptides (AMPs) may represent potential candidates for the treatment of infections caused by multiresistant microorganisms. In this narrative review, we reported the experience of our research group over 20 years. We described the AMPs we evaluated against Gram-positive, Gram-negative, and fungi. In conclusion, our experience shows that AMPs can be a key option for treating multiresistant infections and overcoming resistance mechanisms. The combination of AMPs allows antibiotics and antifungals that are no longer effective to exploit the synergistic effect by restoring their efficacy. A current limitation includes poor data on human patients, the cost of some AMPs, and their safety, which is why studies on humans are needed as soon as possible. |
| first_indexed | 2024-03-09T11:28:20Z |
| format | Article |
| id | doaj.art-47c4287ced2440ac85fb2d0b20d0f88e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:28:20Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-47c4287ced2440ac85fb2d0b20d0f88e2023-11-30T23:56:50ZengMDPI AGPharmaceutics1999-49232022-12-011514010.3390/pharmaceutics15010040Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and FungiGiulio Rizzetto0Daisy Gambini1Andrea Maurizi2Matteo Candelora3Elisa Molinelli4Oscar Cirioni5Lucia Brescini6Andrea Giacometti7Annamaria Offidani8Oriana Simonetti9Clinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Infectious Diseases, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Infectious Diseases, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Infectious Diseases, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, ItalyClinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, ItalyAntibiotic resistance is rapidly increasing, and new anti-infective therapies are urgently needed. In this regard, antimicrobial peptides (AMPs) may represent potential candidates for the treatment of infections caused by multiresistant microorganisms. In this narrative review, we reported the experience of our research group over 20 years. We described the AMPs we evaluated against Gram-positive, Gram-negative, and fungi. In conclusion, our experience shows that AMPs can be a key option for treating multiresistant infections and overcoming resistance mechanisms. The combination of AMPs allows antibiotics and antifungals that are no longer effective to exploit the synergistic effect by restoring their efficacy. A current limitation includes poor data on human patients, the cost of some AMPs, and their safety, which is why studies on humans are needed as soon as possible.https://www.mdpi.com/1999-4923/15/1/40anti-microbial peptidesantibiotic resistanceGram-positive Gram-negativefungi |
| spellingShingle | Giulio Rizzetto Daisy Gambini Andrea Maurizi Matteo Candelora Elisa Molinelli Oscar Cirioni Lucia Brescini Andrea Giacometti Annamaria Offidani Oriana Simonetti Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi Pharmaceutics anti-microbial peptides antibiotic resistance Gram-positive Gram-negative fungi |
| title | Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi |
| title_full | Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi |
| title_fullStr | Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi |
| title_full_unstemmed | Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi |
| title_short | Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi |
| title_sort | our experience over 20 years antimicrobial peptides against gram positives gram negatives and fungi |
| topic | anti-microbial peptides antibiotic resistance Gram-positive Gram-negative fungi |
| url | https://www.mdpi.com/1999-4923/15/1/40 |
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