Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective
Computed tomography (CT) and magnetic resonance imaging (MRI) provide key structural information on brain pathophysiology. Positron emission tomography (PET) measures metabolism in the living brain; it plays an important role in molecular neuroimaging and is rapidly expanding its field of applicatio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-12-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206172 |
| _version_ | 1797365846432022528 |
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| author | Ferdinando Calabria Mario Leporace Andrea Cimini Maria Ricci Laura Travascio Antonio Bagnato |
| author_facet | Ferdinando Calabria Mario Leporace Andrea Cimini Maria Ricci Laura Travascio Antonio Bagnato |
| author_sort | Ferdinando Calabria |
| collection | DOAJ |
| description | Computed tomography (CT) and magnetic resonance imaging (MRI) provide key structural information on brain pathophysiology. Positron emission tomography (PET) measures metabolism in the living brain; it plays an important role in molecular neuroimaging and is rapidly expanding its field of application to the study of neurodegenerative diseases. Different PET radiopharmaceuticals allow in vivo characterization and quantization of biological processes at the molecular and cellular levels, from which many neurodegenerative diseases develop. In addition, hybrid imaging tools such as PET/CT and PET/MRI support the utility of PET, enabling the anatomical mapping of functional data. In this overview, we describe the most commonly used PET tracers in the diagnostic work-up of patients with Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. We also briefly discuss the pathophysiological processes of tracer uptake in the brain, detailing their specific cellular pathways in clinical cases. This overview is limited to imaging agents already applied in human subjects, with particular emphasis on those tracers used in our department. |
| first_indexed | 2024-03-08T16:54:48Z |
| format | Article |
| id | doaj.art-47c4d2d170eb49dfbc91723c5a13ca20 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-08T16:54:48Z |
| publishDate | 2023-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-47c4d2d170eb49dfbc91723c5a13ca202024-01-05T02:39:08ZengIMR PressJournal of Integrative Neuroscience0219-63522023-12-0122617210.31083/j.jin2206172S0219-6352(23)00611-3Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's PerspectiveFerdinando Calabria0Mario Leporace1Andrea Cimini2Maria Ricci3Laura Travascio4Antonio Bagnato5Department of Nuclear Medicine and Theragnostics, Mariano Santo Hospital, 87100 Cosenza, ItalyDepartment of Nuclear Medicine and Theragnostics, Mariano Santo Hospital, 87100 Cosenza, ItalyNuclear Medicine Unit, St Salvatore Hospital, 67100 L’Aquila, ItalyNuclear Medicine Unit, Cardarelli Hospital, 86100 Campobasso, ItalyUnità Operativa Complessa (UOC) of Nuclear Medicine, Pescara Hospital, 65124 Pescara, ItalyDepartment of Nuclear Medicine and Theragnostics, Mariano Santo Hospital, 87100 Cosenza, ItalyComputed tomography (CT) and magnetic resonance imaging (MRI) provide key structural information on brain pathophysiology. Positron emission tomography (PET) measures metabolism in the living brain; it plays an important role in molecular neuroimaging and is rapidly expanding its field of application to the study of neurodegenerative diseases. Different PET radiopharmaceuticals allow in vivo characterization and quantization of biological processes at the molecular and cellular levels, from which many neurodegenerative diseases develop. In addition, hybrid imaging tools such as PET/CT and PET/MRI support the utility of PET, enabling the anatomical mapping of functional data. In this overview, we describe the most commonly used PET tracers in the diagnostic work-up of patients with Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. We also briefly discuss the pathophysiological processes of tracer uptake in the brain, detailing their specific cellular pathways in clinical cases. This overview is limited to imaging agents already applied in human subjects, with particular emphasis on those tracers used in our department.https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206172petamyloid imagingtau proteinmolecular imagingneurodegenerative diseases[18f]fdopa[18f]fdgmri |
| spellingShingle | Ferdinando Calabria Mario Leporace Andrea Cimini Maria Ricci Laura Travascio Antonio Bagnato Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective Journal of Integrative Neuroscience pet amyloid imaging tau protein molecular imaging neurodegenerative diseases [18f]fdopa [18f]fdg mri |
| title | Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective |
| title_full | Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective |
| title_fullStr | Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective |
| title_full_unstemmed | Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective |
| title_short | Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective |
| title_sort | positron emission tomography molecular imaging of the major neurodegenerative disorders overview and pictorial essay from a nuclear medicine center s perspective |
| topic | pet amyloid imaging tau protein molecular imaging neurodegenerative diseases [18f]fdopa [18f]fdg mri |
| url | https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206172 |
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