Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations
Auditory verbal hallucinations (AVH) are a key symptom of schizophrenia (SZ) defined by anomalous perception of speech. Anomalies of processing external speech stimuli have also been reported in people with AVH, but it is unexplored which specific dimensions of language are processed differently. Us...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222000729 |
| _version_ | 1818008784326361088 |
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| author | Paola Fuentes-Claramonte Joan Soler-Vidal Pilar Salgado-Pineda Nuria Ramiro Maria Angeles Garcia-Leon Ramon Cano Antonio Arévalo Josep Munuera Francisco Portillo Francesco Panicali Salvador Sarró Edith Pomarol-Clotet Peter McKenna Wolfram Hinzen |
| author_facet | Paola Fuentes-Claramonte Joan Soler-Vidal Pilar Salgado-Pineda Nuria Ramiro Maria Angeles Garcia-Leon Ramon Cano Antonio Arévalo Josep Munuera Francisco Portillo Francesco Panicali Salvador Sarró Edith Pomarol-Clotet Peter McKenna Wolfram Hinzen |
| author_sort | Paola Fuentes-Claramonte |
| collection | DOAJ |
| description | Auditory verbal hallucinations (AVH) are a key symptom of schizophrenia (SZ) defined by anomalous perception of speech. Anomalies of processing external speech stimuli have also been reported in people with AVH, but it is unexplored which specific dimensions of language are processed differently. Using a speech perception task (passive listening), we here targeted the processing of deixis, a key dimension of language governing the contextual anchoring of speech in interpersonal context. We designed naturalistic speech stimuli that were either non-personal and fact-reporting (‘low-deixis’ condition), or else involved rich deictic devices such as the grammatical first and second persons, direct questions, and vocatives (‘high-deixis’). We asked whether neural correlates of deixis obtained with fMRI would distinguish patients with and without frequent hallucinations (AVH + vs AVH−) from controls and each other. Results showed that high-deixis relative to low-deixis was associated with clusters of increased activation in the bilateral middle temporal gyri extending into the temporal poles and the inferior parietal cortex, in all groups. The AVH + and AVH− groups did not differ. When unifying them, the SZ group as a whole showed altered activity in the precuneus, midline regions and inferior parietal cortex. These results fail to confirm deictic processing anomalies specific to patients with AVH, but reveal such anomalies across SZ. Hypoactivation of this network may relate to a cognitive mechanism for attributing and anchoring thought and referential speech content in context. |
| first_indexed | 2024-04-14T05:34:37Z |
| format | Article |
| id | doaj.art-47c51da7d17d43dfa61fd8a2bec4d67a |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-14T05:34:37Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-47c51da7d17d43dfa61fd8a2bec4d67a2022-12-22T02:09:42ZengElsevierNeuroImage: Clinical2213-15822022-01-0134103007Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinationsPaola Fuentes-Claramonte0Joan Soler-Vidal1Pilar Salgado-Pineda2Nuria Ramiro3Maria Angeles Garcia-Leon4Ramon Cano5Antonio Arévalo6Josep Munuera7Francisco Portillo8Francesco Panicali9Salvador Sarró10Edith Pomarol-Clotet11Peter McKenna12Wolfram Hinzen13FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain; Benito Menni Complex Assistencial en Salut Mental, Germanes Hospitalàries, Sant Boi de Llobregat, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, SpainHospital Sant Rafael, Germanes Hospitalàries, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, SpainHospital Mare de Déu de la Mercè, Germanes Hospitalàries, Barcelona, SpainHospital Sagrat Cor, Germanes Hospitalàries, Martorell, SpainHospital Sant Joan de Déu, Esplugues de Llobregat, SpainBenito Menni Complex Assistencial en Salut Mental, Germanes Hospitalàries, Sant Boi de Llobregat, SpainBenito Menni Complex Assistencial en Salut Mental, Germanes Hospitalàries, Sant Boi de Llobregat, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, SpainUniversitat Pompeu Fabra, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Corresponding author at: Universitat Pompeu Fabra, Carrer de Roc Boronat, 138, 08018 Barcelona, Spain.Auditory verbal hallucinations (AVH) are a key symptom of schizophrenia (SZ) defined by anomalous perception of speech. Anomalies of processing external speech stimuli have also been reported in people with AVH, but it is unexplored which specific dimensions of language are processed differently. Using a speech perception task (passive listening), we here targeted the processing of deixis, a key dimension of language governing the contextual anchoring of speech in interpersonal context. We designed naturalistic speech stimuli that were either non-personal and fact-reporting (‘low-deixis’ condition), or else involved rich deictic devices such as the grammatical first and second persons, direct questions, and vocatives (‘high-deixis’). We asked whether neural correlates of deixis obtained with fMRI would distinguish patients with and without frequent hallucinations (AVH + vs AVH−) from controls and each other. Results showed that high-deixis relative to low-deixis was associated with clusters of increased activation in the bilateral middle temporal gyri extending into the temporal poles and the inferior parietal cortex, in all groups. The AVH + and AVH− groups did not differ. When unifying them, the SZ group as a whole showed altered activity in the precuneus, midline regions and inferior parietal cortex. These results fail to confirm deictic processing anomalies specific to patients with AVH, but reveal such anomalies across SZ. Hypoactivation of this network may relate to a cognitive mechanism for attributing and anchoring thought and referential speech content in context.http://www.sciencedirect.com/science/article/pii/S2213158222000729DeixisLanguageSchizophreniaAuditory verbal hallucinations |
| spellingShingle | Paola Fuentes-Claramonte Joan Soler-Vidal Pilar Salgado-Pineda Nuria Ramiro Maria Angeles Garcia-Leon Ramon Cano Antonio Arévalo Josep Munuera Francisco Portillo Francesco Panicali Salvador Sarró Edith Pomarol-Clotet Peter McKenna Wolfram Hinzen Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations NeuroImage: Clinical Deixis Language Schizophrenia Auditory verbal hallucinations |
| title | Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations |
| title_full | Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations |
| title_fullStr | Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations |
| title_full_unstemmed | Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations |
| title_short | Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations |
| title_sort | processing of linguistic deixis in people with schizophrenia with and without auditory verbal hallucinations |
| topic | Deixis Language Schizophrenia Auditory verbal hallucinations |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222000729 |
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