Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis

Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis

Bone marrow mesenchymal stromal cells (MSCs) have immunomodulatory and regenerative potential. However, culture conditions govern their metabolic processes and therapeutic efficacy. Here we show that culturing donor-derived MSCs in Plasmax™, a physiological medium with the concentrations of nutrient...

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Bibliographic Details
Main Authors: Giuseppe Taurino, Ruhi Deshmukh, Victor H. Villar, Martina Chiu, Robin Shaw, Ann Hedley, Engy Shokry, David Sumpton, Erica Dander, Giovanna D'Amico, Ovidio Bussolati, Saverio Tardito
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Metabolism
Subjects:
Mesenchymal stromal cells
Metabolism
Physiological medium
Plasmax
Hypoxia
Stable isotope tracing
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001016

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http://www.sciencedirect.com/science/article/pii/S2212877822001016

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