Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis
Corona virus disease 2019 (COVID-19) is a global public health crisis. The high infectivity of the disease even from non-symptomatic infected patients, together with the lack of a definitive cure or preventive measures are all responsible for disease outbreak. The severity of COVID-19 seems to be mo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.587866/full |
| _version_ | 1828532334007156736 |
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| author | Dina H. Kassem Mohamed M. Kamal Mohamed M. Kamal Mohamed M. Kamal |
| author_facet | Dina H. Kassem Mohamed M. Kamal Mohamed M. Kamal Mohamed M. Kamal |
| author_sort | Dina H. Kassem |
| collection | DOAJ |
| description | Corona virus disease 2019 (COVID-19) is a global public health crisis. The high infectivity of the disease even from non-symptomatic infected patients, together with the lack of a definitive cure or preventive measures are all responsible for disease outbreak. The severity of COVID-19 seems to be mostly dependent on the patients’ own immune response. The over-activation of the immune system in an attempt to kill the virus, can cause a “cytokine storm” which in turn can induce acute respiratory distress syndrome (ARDS), as well as multi-organ damage, and ultimately may lead to death. Thus, harnessing the immunomodulatory properties of mesenchymal stem cells (MSCs) to ameliorate that cytokine-storm can indeed provide a golden key for the treatment of COVID-19 patients, especially severe cases. In fact, MSCs transplantation can improve the overall outcome of COVID-19 patients via multiple mechanisms; first through their immunomodulatory effects which will help to regulate the infected patient inflammatory response, second via promoting tissue-repair and regeneration, and third through their antifibrotic effects. All these mechanisms will interplay and intervene together to enhance lung-repair and protect various organs from any damage resulting from exaggerated immune-response. A therapeutic modality which provides all these mechanisms undoubtedly hold a strong potential to help COVID-19 patients even those with the worst condition to hopefully survive and recover. |
| first_indexed | 2024-12-11T22:50:40Z |
| format | Article |
| id | doaj.art-47c81e559d614cbb9aa35f89f9e5bdf8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T22:50:40Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-47c81e559d614cbb9aa35f89f9e5bdf82022-12-22T00:47:26ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-09-01810.3389/fcell.2020.587866587866Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 CrisisDina H. Kassem0Mohamed M. Kamal1Mohamed M. Kamal2Mohamed M. Kamal3Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, EgyptDepartment of Pharmacology and Biochemistry, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, EgyptThe Centre for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, EgyptCorona virus disease 2019 (COVID-19) is a global public health crisis. The high infectivity of the disease even from non-symptomatic infected patients, together with the lack of a definitive cure or preventive measures are all responsible for disease outbreak. The severity of COVID-19 seems to be mostly dependent on the patients’ own immune response. The over-activation of the immune system in an attempt to kill the virus, can cause a “cytokine storm” which in turn can induce acute respiratory distress syndrome (ARDS), as well as multi-organ damage, and ultimately may lead to death. Thus, harnessing the immunomodulatory properties of mesenchymal stem cells (MSCs) to ameliorate that cytokine-storm can indeed provide a golden key for the treatment of COVID-19 patients, especially severe cases. In fact, MSCs transplantation can improve the overall outcome of COVID-19 patients via multiple mechanisms; first through their immunomodulatory effects which will help to regulate the infected patient inflammatory response, second via promoting tissue-repair and regeneration, and third through their antifibrotic effects. All these mechanisms will interplay and intervene together to enhance lung-repair and protect various organs from any damage resulting from exaggerated immune-response. A therapeutic modality which provides all these mechanisms undoubtedly hold a strong potential to help COVID-19 patients even those with the worst condition to hopefully survive and recover.https://www.frontiersin.org/article/10.3389/fcell.2020.587866/fullCOVID-19cytokine stormextracellular vesiclesexosomesimmunomodulationmesenchymal stem cells |
| spellingShingle | Dina H. Kassem Mohamed M. Kamal Mohamed M. Kamal Mohamed M. Kamal Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis Frontiers in Cell and Developmental Biology COVID-19 cytokine storm extracellular vesicles exosomes immunomodulation mesenchymal stem cells |
| title | Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis |
| title_full | Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis |
| title_fullStr | Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis |
| title_full_unstemmed | Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis |
| title_short | Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis |
| title_sort | mesenchymal stem cells and their extracellular vesicles a potential game changer for the covid 19 crisis |
| topic | COVID-19 cytokine storm extracellular vesicles exosomes immunomodulation mesenchymal stem cells |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.587866/full |
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