| 总结: | Galactomannans are natural biopolymers possessing efficient biocompatibility, biodegradability, and sustainability, leading to diverse industrial applications. The present work aimed to synthesize a novel hydrogel for drug delivery systems using Cassia galactomannan (galactose to mannose ratio, 1/5) and sodium trimetaphosphate. The hydrogels are used as sustained drug delivery agents for colon cancer treatments and other colonic diseases. The zero order, first order, Higuchi's and Korsmeyer-Peppas models were used to study the release kinetics of the drug, (±)-2-(p-isobutylphenyl)propionic acid. The gels possess controlled water absorption, solubility and increased stability, a requirement for controlled drug delivery applications. The studies reveal that the lower and higher cross-ligate hydrogels were effective in sustained release of 27 and 10 % drug respectively in 24 h. Korsmeyer-Peppas kinetic model showed that the drug release mechanism is controlled diffusion from polymeric gel matrix. Nuclear magnetic spectroscopy 31P, 1H, 13C, DEPT, COSY, HSQC and infrared spectroscopy (FT-IR) proved the formation of new covalent bonds between phosphate and hydroxyls groups that reinforced hydrogel into effective network density and controlled swelling power.
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