Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms
Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with hig...
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MDPI AG
2018-11-01
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| Series: | Behavioral Sciences |
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| Online Access: | https://www.mdpi.com/2076-328X/8/11/102 |
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| author | Hirohito Tsuboi Hiroyuki Sakakibara Yuuki Minamida Hiromasa Tsujiguchi Masahiro Matsunaga Akinori Hara Hiroyuki Nakamura |
| author_facet | Hirohito Tsuboi Hiroyuki Sakakibara Yuuki Minamida Hiromasa Tsujiguchi Masahiro Matsunaga Akinori Hara Hiroyuki Nakamura |
| author_sort | Hirohito Tsuboi |
| collection | DOAJ |
| description | Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with high and low depressive symptoms of a general population. The participants comprised 20 female community-dwellers aged 40 years or older who contributed to a Shika study in Ishikawa, Japan. Ten participants who showed higher and ten who showed lower depressive symptoms among 208 females assessed by the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D) were selected for this study. Serum samples were analyzed for TNF-alpha, IL-6, IL-10, IL-12, and IL-17A using a multiplex Luminex analysis. For the comparison between the high and low depressive groups statistically, linear regression analyses were applied. The serum level of IL-17A was significantly higher among the high depressive participants (<i>p</i> < 0.05) even after controlling possible confounders, whereas there were no differences in TNF-alpha, IL-6, IL-10, or IL-12 between the high and low depressive groups. Our findings supported an association between serum IL-17A levels and depressive symptoms. Peripheral IL-17A immune response may be a preventive and treatment target for depression. |
| first_indexed | 2024-04-12T12:42:52Z |
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| institution | Directory Open Access Journal |
| issn | 2076-328X |
| language | English |
| last_indexed | 2024-04-12T12:42:52Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Behavioral Sciences |
| spelling | doaj.art-47ccb53cb6da4f9a8ee3844804d8c53d2022-12-22T03:32:45ZengMDPI AGBehavioral Sciences2076-328X2018-11-0181110210.3390/bs8110102bs8110102Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive SymptomsHirohito Tsuboi0Hiroyuki Sakakibara1Yuuki Minamida2Hiromasa Tsujiguchi3Masahiro Matsunaga4Akinori Hara5Hiroyuki Nakamura6Institute of Medical, Pharmaceutical & Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanDepartment of Biochemistry and Applied biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanInstitute of Medical, Pharmaceutical & Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanDepartment of Public Health, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, JapanDepartment of Public Health, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, JapanDepartment of Public Health, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, JapanRecent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with high and low depressive symptoms of a general population. The participants comprised 20 female community-dwellers aged 40 years or older who contributed to a Shika study in Ishikawa, Japan. Ten participants who showed higher and ten who showed lower depressive symptoms among 208 females assessed by the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D) were selected for this study. Serum samples were analyzed for TNF-alpha, IL-6, IL-10, IL-12, and IL-17A using a multiplex Luminex analysis. For the comparison between the high and low depressive groups statistically, linear regression analyses were applied. The serum level of IL-17A was significantly higher among the high depressive participants (<i>p</i> < 0.05) even after controlling possible confounders, whereas there were no differences in TNF-alpha, IL-6, IL-10, or IL-12 between the high and low depressive groups. Our findings supported an association between serum IL-17A levels and depressive symptoms. Peripheral IL-17A immune response may be a preventive and treatment target for depression.https://www.mdpi.com/2076-328X/8/11/102depressive symptomsinterleukin-17community-dwelling women |
| spellingShingle | Hirohito Tsuboi Hiroyuki Sakakibara Yuuki Minamida Hiromasa Tsujiguchi Masahiro Matsunaga Akinori Hara Hiroyuki Nakamura Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms Behavioral Sciences depressive symptoms interleukin-17 community-dwelling women |
| title | Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms |
| title_full | Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms |
| title_fullStr | Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms |
| title_full_unstemmed | Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms |
| title_short | Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms |
| title_sort | elevated levels of serum il 17a in community dwelling women with higher depressive symptoms |
| topic | depressive symptoms interleukin-17 community-dwelling women |
| url | https://www.mdpi.com/2076-328X/8/11/102 |
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