DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers

Abstract Monitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids. These biomarkers released by tumor cells can...

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Main Authors: Yitong Zhu, Wenbin Li, Fei Lan, Siting Chen, Xiaofei Chen, Xiaohe Zhang, Xiaohui Yan, Ye Zhang
Format: Article
Language:English
Published: Wiley-VCH 2024-01-01
Series:Interdisciplinary Medicine
Subjects:
Online Access:https://doi.org/10.1002/INMD.20230043
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author Yitong Zhu
Wenbin Li
Fei Lan
Siting Chen
Xiaofei Chen
Xiaohe Zhang
Xiaohui Yan
Ye Zhang
author_facet Yitong Zhu
Wenbin Li
Fei Lan
Siting Chen
Xiaofei Chen
Xiaohe Zhang
Xiaohui Yan
Ye Zhang
author_sort Yitong Zhu
collection DOAJ
description Abstract Monitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids. These biomarkers released by tumor cells can travel to other parts of the circulation system. The analysis of circulating tumor markers in the circulation enables early tumor diagnosis, progression evolution, and treatment monitoring, which are important for individualized clinical decisions. In this study, we summarize different DNA nanotechnology strategies that can be used to capture, amplify, and measure circulating biomarkers and discuss the current challenges and outlook.
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spelling doaj.art-47cd728986c34560b0a250cf8d7e5abf2024-01-31T16:52:45ZengWiley-VCHInterdisciplinary Medicine2832-62452024-01-0121n/an/a10.1002/INMD.20230043DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkersYitong Zhu0Wenbin Li1Fei Lan2Siting Chen3Xiaofei Chen4Xiaohe Zhang5Xiaohui Yan6Ye Zhang7Department of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaSouthern Methodist University/UT Southwestern Medical Center Dallas Texas USADepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaAbstract Monitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids. These biomarkers released by tumor cells can travel to other parts of the circulation system. The analysis of circulating tumor markers in the circulation enables early tumor diagnosis, progression evolution, and treatment monitoring, which are important for individualized clinical decisions. In this study, we summarize different DNA nanotechnology strategies that can be used to capture, amplify, and measure circulating biomarkers and discuss the current challenges and outlook.https://doi.org/10.1002/INMD.20230043circulating biomarkersDNA nanotechnologyextracellular vesiclestumor liquid biopsy
spellingShingle Yitong Zhu
Wenbin Li
Fei Lan
Siting Chen
Xiaofei Chen
Xiaohe Zhang
Xiaohui Yan
Ye Zhang
DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
Interdisciplinary Medicine
circulating biomarkers
DNA nanotechnology
extracellular vesicles
tumor liquid biopsy
title DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
title_full DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
title_fullStr DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
title_full_unstemmed DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
title_short DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
title_sort dna nanotechnology in tumor liquid biopsy enrichment and determination of circulating biomarkers
topic circulating biomarkers
DNA nanotechnology
extracellular vesicles
tumor liquid biopsy
url https://doi.org/10.1002/INMD.20230043
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