DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers
Abstract Monitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids. These biomarkers released by tumor cells can...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
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Wiley-VCH
2024-01-01
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Series: | Interdisciplinary Medicine |
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Online Access: | https://doi.org/10.1002/INMD.20230043 |
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author | Yitong Zhu Wenbin Li Fei Lan Siting Chen Xiaofei Chen Xiaohe Zhang Xiaohui Yan Ye Zhang |
author_facet | Yitong Zhu Wenbin Li Fei Lan Siting Chen Xiaofei Chen Xiaohe Zhang Xiaohui Yan Ye Zhang |
author_sort | Yitong Zhu |
collection | DOAJ |
description | Abstract Monitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids. These biomarkers released by tumor cells can travel to other parts of the circulation system. The analysis of circulating tumor markers in the circulation enables early tumor diagnosis, progression evolution, and treatment monitoring, which are important for individualized clinical decisions. In this study, we summarize different DNA nanotechnology strategies that can be used to capture, amplify, and measure circulating biomarkers and discuss the current challenges and outlook. |
first_indexed | 2024-03-08T09:16:00Z |
format | Article |
id | doaj.art-47cd728986c34560b0a250cf8d7e5abf |
institution | Directory Open Access Journal |
issn | 2832-6245 |
language | English |
last_indexed | 2024-03-08T09:16:00Z |
publishDate | 2024-01-01 |
publisher | Wiley-VCH |
record_format | Article |
series | Interdisciplinary Medicine |
spelling | doaj.art-47cd728986c34560b0a250cf8d7e5abf2024-01-31T16:52:45ZengWiley-VCHInterdisciplinary Medicine2832-62452024-01-0121n/an/a10.1002/INMD.20230043DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkersYitong Zhu0Wenbin Li1Fei Lan2Siting Chen3Xiaofei Chen4Xiaohe Zhang5Xiaohui Yan6Ye Zhang7Department of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaSouthern Methodist University/UT Southwestern Medical Center Dallas Texas USADepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou ChinaAbstract Monitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids. These biomarkers released by tumor cells can travel to other parts of the circulation system. The analysis of circulating tumor markers in the circulation enables early tumor diagnosis, progression evolution, and treatment monitoring, which are important for individualized clinical decisions. In this study, we summarize different DNA nanotechnology strategies that can be used to capture, amplify, and measure circulating biomarkers and discuss the current challenges and outlook.https://doi.org/10.1002/INMD.20230043circulating biomarkersDNA nanotechnologyextracellular vesiclestumor liquid biopsy |
spellingShingle | Yitong Zhu Wenbin Li Fei Lan Siting Chen Xiaofei Chen Xiaohe Zhang Xiaohui Yan Ye Zhang DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers Interdisciplinary Medicine circulating biomarkers DNA nanotechnology extracellular vesicles tumor liquid biopsy |
title | DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers |
title_full | DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers |
title_fullStr | DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers |
title_full_unstemmed | DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers |
title_short | DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers |
title_sort | dna nanotechnology in tumor liquid biopsy enrichment and determination of circulating biomarkers |
topic | circulating biomarkers DNA nanotechnology extracellular vesicles tumor liquid biopsy |
url | https://doi.org/10.1002/INMD.20230043 |
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