Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain
In the spinal cord, altered protein transcription and translation have received a lot of recent attention for their role in neural plasticity, a major mechanism leading to the development of chronic pain. However, changes in brain plasticity are also associated with the maintenance of pain symptoms,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-08-01
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| Series: | Neurobiology of Pain |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X18300035 |
| _version_ | 1818472137175859200 |
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| author | Chulmin Cho Vassilia Michailidis Loren J. Martin |
| author_facet | Chulmin Cho Vassilia Michailidis Loren J. Martin |
| author_sort | Chulmin Cho |
| collection | DOAJ |
| description | In the spinal cord, altered protein transcription and translation have received a lot of recent attention for their role in neural plasticity, a major mechanism leading to the development of chronic pain. However, changes in brain plasticity are also associated with the maintenance of pain symptoms, but these cellular mechanisms remain less clear. The mechanistic/mammalian target of rapamycin (mTOR) is a master regulator of protein synthesis, and controls several neuronal functions, including neural plasticity. While aberrant changes in mTOR signaling are associated with sensitization of the pain pathway (sensory neurons and spinal cord), there are various nervous system diseases that have pain as a comorbidity and altered mTOR activity in the brain. Here, we provide a brief review of mTOR changes in the brain that are associated with some neurological disorders and focus on how these changes may be relevant to the pain of the underlying condition and chronic pain itself. Keywords: mTOR, Pain, Multiple sclerosis, Depression, Alzheimer’s disease, Parkinson’s disease |
| first_indexed | 2024-04-14T04:02:26Z |
| format | Article |
| id | doaj.art-47ce7e5189154a1fa070716f098b1943 |
| institution | Directory Open Access Journal |
| issn | 2452-073X |
| language | English |
| last_indexed | 2024-04-14T04:02:26Z |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Pain |
| spelling | doaj.art-47ce7e5189154a1fa070716f098b19432022-12-22T02:13:30ZengElsevierNeurobiology of Pain2452-073X2018-08-0142734Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic painChulmin Cho0Vassilia Michailidis1Loren J. Martin2Department of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, CanadaDeptartment of Cell and Systems Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, CanadaDepartment of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada; Deptartment of Cell and Systems Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada; Corresponding author at: Department of Psychology, University of Toronto Mississauga, 3359 Mississauga Rd., Mississauga, ON L5L 1C6, Canada.In the spinal cord, altered protein transcription and translation have received a lot of recent attention for their role in neural plasticity, a major mechanism leading to the development of chronic pain. However, changes in brain plasticity are also associated with the maintenance of pain symptoms, but these cellular mechanisms remain less clear. The mechanistic/mammalian target of rapamycin (mTOR) is a master regulator of protein synthesis, and controls several neuronal functions, including neural plasticity. While aberrant changes in mTOR signaling are associated with sensitization of the pain pathway (sensory neurons and spinal cord), there are various nervous system diseases that have pain as a comorbidity and altered mTOR activity in the brain. Here, we provide a brief review of mTOR changes in the brain that are associated with some neurological disorders and focus on how these changes may be relevant to the pain of the underlying condition and chronic pain itself. Keywords: mTOR, Pain, Multiple sclerosis, Depression, Alzheimer’s disease, Parkinson’s diseasehttp://www.sciencedirect.com/science/article/pii/S2452073X18300035 |
| spellingShingle | Chulmin Cho Vassilia Michailidis Loren J. Martin Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain Neurobiology of Pain |
| title | Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain |
| title_full | Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain |
| title_fullStr | Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain |
| title_full_unstemmed | Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain |
| title_short | Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain |
| title_sort | revealing brain mechanisms of mtor mediated translational regulation implications for chronic pain |
| url | http://www.sciencedirect.com/science/article/pii/S2452073X18300035 |
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