Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever
Background Massive bleeding and shock are complications of dengue hemorrhagic fever (DHF) that are associated with high mortality. Impaired hemostasis, especially coagulopathy, contributes to bleeding manifestations in DHF. Parameters such as activated partial thromboplastin time (APTT) an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2009-04-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/459 |
| Summary: | Background Massive bleeding and shock are complications of
dengue hemorrhagic fever (DHF) that are associated with
high mortality. Impaired hemostasis, especially coagulopathy,
contributes to bleeding manifestations in DHF. Parameters such
as activated partial thromboplastin time (APTT) and plasma
prothrombin time (PPT) indicate the impact of coagulation
system.
Objective To determine the relationship between APTT and PPT
levels with bleeding manifestations in DHF patients.
Methods A prospective cohort study was applied to subjects
diagnosed with DHF at the Infection and Tropical Diseases
Division, Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Indonesia. Laboratory
tests to determine APTT and PPT were carried out on the
third, fourth, and fifth day after the onset of fever. Bleeding
manifestations were examined in patients during their hospital
stay. Univariate and Cox regression analyses were performed
to examine relationship between APTT and PPT values with
bleeding manifestations in DHF patients.
Results Forty-three children were enrolled in this study. There
was a significant relationship between increases in APTT value
with bleeding manifestations in DHF patients [RR 2.79 (95%CI
1.68 to 4.69), P <0.01]. Cox regression analysis showed that only
increased APTT values correlated with bleeding manifestations
[RR 2.05 (95%CI 1.92 to 3.90), P = 0.02].
Conclusion APTT values may be used as a predictor for bleeding
manifestations in DHF. |
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| ISSN: | 0030-9311 2338-476X |