Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever
Background Massive bleeding and shock are complications of dengue hemorrhagic fever (DHF) that are associated with high mortality. Impaired hemostasis, especially coagulopathy, contributes to bleeding manifestations in DHF. Parameters such as activated partial thromboplastin time (APTT) an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2009-04-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/459 |
| _version_ | 1818902249217196032 |
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| author | I. N. Budastra B. N. P. Arhana IB. Mudita |
| author_facet | I. N. Budastra B. N. P. Arhana IB. Mudita |
| author_sort | I. N. Budastra |
| collection | DOAJ |
| description | Background Massive bleeding and shock are complications of
dengue hemorrhagic fever (DHF) that are associated with
high mortality. Impaired hemostasis, especially coagulopathy,
contributes to bleeding manifestations in DHF. Parameters such
as activated partial thromboplastin time (APTT) and plasma
prothrombin time (PPT) indicate the impact of coagulation
system.
Objective To determine the relationship between APTT and PPT
levels with bleeding manifestations in DHF patients.
Methods A prospective cohort study was applied to subjects
diagnosed with DHF at the Infection and Tropical Diseases
Division, Department of Child Health, Medical School, Udayana
University, Sanglah Hospital, Denpasar, Indonesia. Laboratory
tests to determine APTT and PPT were carried out on the
third, fourth, and fifth day after the onset of fever. Bleeding
manifestations were examined in patients during their hospital
stay. Univariate and Cox regression analyses were performed
to examine relationship between APTT and PPT values with
bleeding manifestations in DHF patients.
Results Forty-three children were enrolled in this study. There
was a significant relationship between increases in APTT value
with bleeding manifestations in DHF patients [RR 2.79 (95%CI
1.68 to 4.69), P <0.01]. Cox regression analysis showed that only
increased APTT values correlated with bleeding manifestations
[RR 2.05 (95%CI 1.92 to 3.90), P = 0.02].
Conclusion APTT values may be used as a predictor for bleeding
manifestations in DHF. |
| first_indexed | 2024-12-19T20:32:39Z |
| format | Article |
| id | doaj.art-47d64eef959d4e77be9377fef3cf1e4c |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-19T20:32:39Z |
| publishDate | 2009-04-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-47d64eef959d4e77be9377fef3cf1e4c2022-12-21T20:06:38ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2009-04-01492697410.14238/pi49.2.2009.69-74344Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic feverI. N. BudastraB. N. P. ArhanaIB. MuditaBackground Massive bleeding and shock are complications of dengue hemorrhagic fever (DHF) that are associated with high mortality. Impaired hemostasis, especially coagulopathy, contributes to bleeding manifestations in DHF. Parameters such as activated partial thromboplastin time (APTT) and plasma prothrombin time (PPT) indicate the impact of coagulation system. Objective To determine the relationship between APTT and PPT levels with bleeding manifestations in DHF patients. Methods A prospective cohort study was applied to subjects diagnosed with DHF at the Infection and Tropical Diseases Division, Department of Child Health, Medical School, Udayana University, Sanglah Hospital, Denpasar, Indonesia. Laboratory tests to determine APTT and PPT were carried out on the third, fourth, and fifth day after the onset of fever. Bleeding manifestations were examined in patients during their hospital stay. Univariate and Cox regression analyses were performed to examine relationship between APTT and PPT values with bleeding manifestations in DHF patients. Results Forty-three children were enrolled in this study. There was a significant relationship between increases in APTT value with bleeding manifestations in DHF patients [RR 2.79 (95%CI 1.68 to 4.69), P <0.01]. Cox regression analysis showed that only increased APTT values correlated with bleeding manifestations [RR 2.05 (95%CI 1.92 to 3.90), P = 0.02]. Conclusion APTT values may be used as a predictor for bleeding manifestations in DHF.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/459DHFimpaired coagulationbleedingAPTT |
| spellingShingle | I. N. Budastra B. N. P. Arhana IB. Mudita Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever Paediatrica Indonesiana DHF impaired coagulation bleeding APTT |
| title | Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever |
| title_full | Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever |
| title_fullStr | Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever |
| title_full_unstemmed | Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever |
| title_short | Plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever |
| title_sort | plasma prothrombin time and activated partial thromboplastin time as predictors of bleeding manifestations during dengue hemorrhagic fever |
| topic | DHF impaired coagulation bleeding APTT |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/459 |
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