Somatosensory Mismatch Response in Patients with Cerebral Palsy
Background: Mismatch negativity (MMN), an event-related potential (ERP) component occurring at specific recording sites and latency, is associated with an automatic change detection response, generally elicited using oddball paradigms wherein infrequent stimuli are embedded in repeated, frequent sti...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/14/3/1030 |
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| author | Susmita Roy Stefan K. Ehrlich Renée Lampe |
| author_facet | Susmita Roy Stefan K. Ehrlich Renée Lampe |
| author_sort | Susmita Roy |
| collection | DOAJ |
| description | Background: Mismatch negativity (MMN), an event-related potential (ERP) component occurring at specific recording sites and latency, is associated with an automatic change detection response, generally elicited using oddball paradigms wherein infrequent stimuli are embedded in repeated, frequent stimuli. To verify the presence of mismatch-related ERP responses to somatosensory stimulation in individuals with cerebral palsy (CP), we conducted a preliminary study involving healthy participants and patients with CP. Methods: Both groups underwent ‘frequent’ and ’infrequent’ stimulation applied to the ring finger and thumb of their left hand, respectively. ERPs were recorded at frontal, central, and parietal scalp locations using electroencephalography. A healthy cohort tested the experimental protocol and showed evidence that mismatch-related ERP responses were observable. Subsequent analysis focused on the patient group. Results: Statistically significant differences between the two types of stimuli were observed on the frontocentral and parietal channels between 150 and 250 ms after the stimulus onset in the patient group. Furthermore, a late discriminative response was observed in the frontal and parietal channels. Conclusion: The results demonstrate the presence of mismatch-related ERP responses in individuals with CP. |
| first_indexed | 2024-03-08T04:01:27Z |
| format | Article |
| id | doaj.art-47d657f8c2284feeac647ef241dd3260 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-08T04:01:27Z |
| publishDate | 2024-01-01 |
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| record_format | Article |
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| spelling | doaj.art-47d657f8c2284feeac647ef241dd32602024-02-09T15:07:25ZengMDPI AGApplied Sciences2076-34172024-01-01143103010.3390/app14031030Somatosensory Mismatch Response in Patients with Cerebral PalsySusmita Roy0Stefan K. Ehrlich1Renée Lampe2Research Unit of the Buhl-Strohmaier Foundation for Cerebral Palsy and Pediatric Neuroorthopaedics, Department of Orthopaedics and Sports Orthopaedics, TUM School of Medicine and Health, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, GermanySETLabs Research GmbH, Healthcare Technologies, Elsenheimerstrasse 55, 80687 Munich, GermanyResearch Unit of the Buhl-Strohmaier Foundation for Cerebral Palsy and Pediatric Neuroorthopaedics, Department of Orthopaedics and Sports Orthopaedics, TUM School of Medicine and Health, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, GermanyBackground: Mismatch negativity (MMN), an event-related potential (ERP) component occurring at specific recording sites and latency, is associated with an automatic change detection response, generally elicited using oddball paradigms wherein infrequent stimuli are embedded in repeated, frequent stimuli. To verify the presence of mismatch-related ERP responses to somatosensory stimulation in individuals with cerebral palsy (CP), we conducted a preliminary study involving healthy participants and patients with CP. Methods: Both groups underwent ‘frequent’ and ’infrequent’ stimulation applied to the ring finger and thumb of their left hand, respectively. ERPs were recorded at frontal, central, and parietal scalp locations using electroencephalography. A healthy cohort tested the experimental protocol and showed evidence that mismatch-related ERP responses were observable. Subsequent analysis focused on the patient group. Results: Statistically significant differences between the two types of stimuli were observed on the frontocentral and parietal channels between 150 and 250 ms after the stimulus onset in the patient group. Furthermore, a late discriminative response was observed in the frontal and parietal channels. Conclusion: The results demonstrate the presence of mismatch-related ERP responses in individuals with CP.https://www.mdpi.com/2076-3417/14/3/1030mismatch negativityEEGsomatosensory stimulicerebral palsycognitive enhancement |
| spellingShingle | Susmita Roy Stefan K. Ehrlich Renée Lampe Somatosensory Mismatch Response in Patients with Cerebral Palsy Applied Sciences mismatch negativity EEG somatosensory stimuli cerebral palsy cognitive enhancement |
| title | Somatosensory Mismatch Response in Patients with Cerebral Palsy |
| title_full | Somatosensory Mismatch Response in Patients with Cerebral Palsy |
| title_fullStr | Somatosensory Mismatch Response in Patients with Cerebral Palsy |
| title_full_unstemmed | Somatosensory Mismatch Response in Patients with Cerebral Palsy |
| title_short | Somatosensory Mismatch Response in Patients with Cerebral Palsy |
| title_sort | somatosensory mismatch response in patients with cerebral palsy |
| topic | mismatch negativity EEG somatosensory stimuli cerebral palsy cognitive enhancement |
| url | https://www.mdpi.com/2076-3417/14/3/1030 |
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