Faecal bile acids are natural ligands of the mouse accessory olfactory system

The accessory olfactory system (AOS) processes social chemosensory information and guides behaviors that are important for survival and reproduction in mammals. Here the authors report that mouse feces are a source of AOS neuronal activity and identify unconjugated bile acids in feces as a class of...

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Main Authors: Wayne I. Doyle, Jordan A. Dinser, Hillary L. Cansler, Xingjian Zhang, Daniel D. Dinh, Natasha S. Browder, Ian M. Riddington, Julian P. Meeks
Format: Article
Language:English
Published: Nature Portfolio 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11936
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author Wayne I. Doyle
Jordan A. Dinser
Hillary L. Cansler
Xingjian Zhang
Daniel D. Dinh
Natasha S. Browder
Ian M. Riddington
Julian P. Meeks
author_facet Wayne I. Doyle
Jordan A. Dinser
Hillary L. Cansler
Xingjian Zhang
Daniel D. Dinh
Natasha S. Browder
Ian M. Riddington
Julian P. Meeks
author_sort Wayne I. Doyle
collection DOAJ
description The accessory olfactory system (AOS) processes social chemosensory information and guides behaviors that are important for survival and reproduction in mammals. Here the authors report that mouse feces are a source of AOS neuronal activity and identify unconjugated bile acids in feces as a class of natural AOS ligands.
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spelling doaj.art-47d77c791ff04685ae9a2e6041c532d82022-12-21T18:03:54ZengNature PortfolioNature Communications2041-17232016-06-017111210.1038/ncomms11936Faecal bile acids are natural ligands of the mouse accessory olfactory systemWayne I. Doyle0Jordan A. Dinser1Hillary L. Cansler2Xingjian Zhang3Daniel D. Dinh4Natasha S. Browder5Ian M. Riddington6Julian P. Meeks7Department of Neuroscience, The University of Texas Southwestern Medical CenterDepartment of Chemistry, The University of TexasDepartment of Neuroscience, The University of Texas Southwestern Medical CenterDepartment of Neuroscience, The University of Texas Southwestern Medical CenterDepartment of Neuroscience, The University of Texas Southwestern Medical CenterDepartment of Neuroscience, The University of Texas Southwestern Medical CenterDepartment of Chemistry, The University of TexasDepartment of Neuroscience, The University of Texas Southwestern Medical CenterThe accessory olfactory system (AOS) processes social chemosensory information and guides behaviors that are important for survival and reproduction in mammals. Here the authors report that mouse feces are a source of AOS neuronal activity and identify unconjugated bile acids in feces as a class of natural AOS ligands.https://doi.org/10.1038/ncomms11936
spellingShingle Wayne I. Doyle
Jordan A. Dinser
Hillary L. Cansler
Xingjian Zhang
Daniel D. Dinh
Natasha S. Browder
Ian M. Riddington
Julian P. Meeks
Faecal bile acids are natural ligands of the mouse accessory olfactory system
Nature Communications
title Faecal bile acids are natural ligands of the mouse accessory olfactory system
title_full Faecal bile acids are natural ligands of the mouse accessory olfactory system
title_fullStr Faecal bile acids are natural ligands of the mouse accessory olfactory system
title_full_unstemmed Faecal bile acids are natural ligands of the mouse accessory olfactory system
title_short Faecal bile acids are natural ligands of the mouse accessory olfactory system
title_sort faecal bile acids are natural ligands of the mouse accessory olfactory system
url https://doi.org/10.1038/ncomms11936
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