Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol)
Abstract Turner syndrome (TS; ORPHA 881) is a rare condition in which all or part of one X chromosome is absent from some or all cells. It affects approximately one in every 1/2500 liveborn girls. The most frequently observed karyotypes are 45,X (40–50%) and the 45,X/46,XX mosaic karyotype (15–25%)....
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
|
| Series: | Orphanet Journal of Rare Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13023-022-02423-5 |
| _version_ | 1828543178843619328 |
|---|---|
| author | Elodie Fiot Bertille Alauze Bruno Donadille Dinane Samara-Boustani Muriel Houang Gianpaolo De Filippo Anne Bachelot Clemence Delcour Constance Beyler Emilie Bois Emmanuelle Bourrat Emmanuel Bui Quoc Nathalie Bourcigaux Catherine Chaussain Ariel Cohen Martine Cohen-Solal Sabrina Da Costa Claire Dossier Stephane Ederhy Monique Elmaleh Laurence Iserin Hélène Lengliné Armelle Poujol-Robert Dominique Roulot Jerome Viala Frederique Albarel Elise Bismuth Valérie Bernard Claire Bouvattier Aude Brac Patricia Bretones Nathalie Chabbert-Buffet Philippe Chanson Regis Coutant Marguerite de Warren Béatrice Demaret Lise Duranteau Florence Eustache Lydie Gautheret Georges Gelwane Claire Gourbesville Mickaël Grynberg Karinne Gueniche Carina Jorgensen Veronique Kerlan Charlotte Lebrun Christine Lefevre Françoise Lorenzini Sylvie Manouvrier Catherine Pienkowski Rachel Reynaud Yves Reznik Jean-Pierre Siffroi Anne-Claude Tabet Maithé Tauber Vanessa Vautier Igor Tauveron Sebastien Wambre Delphine Zenaty Irène Netchine Michel Polak Philippe Touraine Jean-Claude Carel Sophie Christin-Maitre Juliane Léger |
| author_facet | Elodie Fiot Bertille Alauze Bruno Donadille Dinane Samara-Boustani Muriel Houang Gianpaolo De Filippo Anne Bachelot Clemence Delcour Constance Beyler Emilie Bois Emmanuelle Bourrat Emmanuel Bui Quoc Nathalie Bourcigaux Catherine Chaussain Ariel Cohen Martine Cohen-Solal Sabrina Da Costa Claire Dossier Stephane Ederhy Monique Elmaleh Laurence Iserin Hélène Lengliné Armelle Poujol-Robert Dominique Roulot Jerome Viala Frederique Albarel Elise Bismuth Valérie Bernard Claire Bouvattier Aude Brac Patricia Bretones Nathalie Chabbert-Buffet Philippe Chanson Regis Coutant Marguerite de Warren Béatrice Demaret Lise Duranteau Florence Eustache Lydie Gautheret Georges Gelwane Claire Gourbesville Mickaël Grynberg Karinne Gueniche Carina Jorgensen Veronique Kerlan Charlotte Lebrun Christine Lefevre Françoise Lorenzini Sylvie Manouvrier Catherine Pienkowski Rachel Reynaud Yves Reznik Jean-Pierre Siffroi Anne-Claude Tabet Maithé Tauber Vanessa Vautier Igor Tauveron Sebastien Wambre Delphine Zenaty Irène Netchine Michel Polak Philippe Touraine Jean-Claude Carel Sophie Christin-Maitre Juliane Léger |
| author_sort | Elodie Fiot |
| collection | DOAJ |
| description | Abstract Turner syndrome (TS; ORPHA 881) is a rare condition in which all or part of one X chromosome is absent from some or all cells. It affects approximately one in every 1/2500 liveborn girls. The most frequently observed karyotypes are 45,X (40–50%) and the 45,X/46,XX mosaic karyotype (15–25%). Karyotypes with an X isochromosome (45,X/46,isoXq or 45,X/46,isoXp), a Y chromosome, X ring chromosome or deletions of the X chromosome are less frequent. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins) is to provide health professionals with information about the optimal management and care for patients, based on a critical literature review and multidisciplinary expert consensus. The PNDS, written by members of the French National Reference Center for Rare Growth and Developmental Endocrine disorders, is available from the French Health Authority website. Turner Syndrome is associated with several phenotypic conditions and a higher risk of comorbidity. The most frequently reported features are growth retardation with short adult stature and gonadal dysgenesis. TS may be associated with various congenital (heart and kidney) or acquired diseases (autoimmune thyroid disease, celiac disease, hearing loss, overweight/obesity, glucose intolerance/type 2 diabetes, dyslipidemia, cardiovascular complications and liver dysfunction). Most of the clinical traits of TS are due to the haploinsufficiency of various genes on the X chromosome, particularly those in the pseudoautosomal regions (PAR 1 and PAR 2), which normally escape the physiological process of X inactivation, although other regions may also be implicated. The management of patients with TS requires collaboration between several healthcare providers. The attending physician, in collaboration with the national care network, will ensure that the patient receives optimal care through regular follow-up and screening. The various elements of this PNDS are designed to provide such support. |
| first_indexed | 2024-12-12T02:09:26Z |
| format | Article |
| id | doaj.art-47d7e0d1bd19414b82a3ff48728cebb1 |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-12-12T02:09:26Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-47d7e0d1bd19414b82a3ff48728cebb12022-12-22T00:41:57ZengBMCOrphanet Journal of Rare Diseases1750-11722022-07-0117S113910.1186/s13023-022-02423-5Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol)Elodie Fiot0Bertille Alauze1Bruno Donadille2Dinane Samara-Boustani3Muriel Houang4Gianpaolo De Filippo5Anne Bachelot6Clemence Delcour7Constance Beyler8Emilie Bois9Emmanuelle Bourrat10Emmanuel Bui Quoc11Nathalie Bourcigaux12Catherine Chaussain13Ariel Cohen14Martine Cohen-Solal15Sabrina Da Costa16Claire Dossier17Stephane Ederhy18Monique Elmaleh19Laurence Iserin20Hélène Lengliné21Armelle Poujol-Robert22Dominique Roulot23Jerome Viala24Frederique Albarel25Elise Bismuth26Valérie Bernard27Claire Bouvattier28Aude Brac29Patricia Bretones30Nathalie Chabbert-Buffet31Philippe Chanson32Regis Coutant33Marguerite de Warren34Béatrice Demaret35Lise Duranteau36Florence Eustache37Lydie Gautheret38Georges Gelwane39Claire Gourbesville40Mickaël Grynberg41Karinne Gueniche42Carina Jorgensen43Veronique Kerlan44Charlotte Lebrun45Christine Lefevre46Françoise Lorenzini47Sylvie Manouvrier48Catherine Pienkowski49Rachel Reynaud50Yves Reznik51Jean-Pierre Siffroi52Anne-Claude Tabet53Maithé Tauber54Vanessa Vautier55Igor Tauveron56Sebastien Wambre57Delphine Zenaty58Irène Netchine59Michel Polak60Philippe Touraine61Jean-Claude Carel62Sophie Christin-Maitre63Juliane Léger64Pediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalDepartment of Reproductive Endocrinology, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Saint Antoine HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Université de Paris, Necker Enfants Malades University HospitalExplorations Fonctionnelles Endocriniennes, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Armand-Trousseau HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalEndocrinology and Reproductive Medicine Department, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Pitié Salpétrière University HospitalDepartment of Obstetrics and Gynecology, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalCardiopaediatric Unit, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalPediatric Otorhinolaryngology Department, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalDermatology Unit, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalOphthalmology Department, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalDepartment of Reproductive Endocrinology, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Saint Antoine HospitalOdontology Department, Assistance Publique-Hôpitaux de Paris, University Hospitals Charles Foix, PNVS, and Henri MondorDepartment of Cardiology, GRC n°27, GRECO, AP-HP, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Saint Antoine HospitalDepartment of Rheumatology, Assistance Publique-Hôpitaux de Paris, Université de Paris, Lariboisière HospitalReference Center for Rare Gynecological Pathologies, Pediatric Endocrinology Department, Assistance Publique-Hôpitaux de Paris, Université de Paris, Necker Enfants Malades University HospitalDepartment of Paediatric Nephrology, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalDepartment of Cardiology, GRC n°27, GRECO, AP-HP, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Saint Antoine HospitalDepartment of Radiology, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalAdult Congenital Heart Disease Unit, Cardiology Department, Assistance Publique-Hôpitaux de Paris, Université de Paris, Georges Pompidou University HospitalDepartment of Pediatric Gastroenterology and Nutrition, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalHepatology Department, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Saint Antoine HospitalHepatology Department, Assistance Publique-Hopitaux de Paris, Université Sorbonne Paris Nord, Avicenne HospitalDepartment of Pediatric Gastroenterology and Nutrition, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalDepartment of Endocrinology, Assistance Publique-Hôpitaux de Marseille. Hospital La ConceptionDepartment of Pediatric Endocrinology and Diabetology, Competence Center for Rare Diseases of Insulin Secretion and Insulin Sensitivity, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalCHU Pellegrin, Department of Gynecological Surgery, Medical Gynecology and Reproductive Medicine, Centre Aliénor d’aquitaine, Bordeaux University HospitalsPaediatric Endocrinology Department, Reference Center for Rare Genital Development Disorders, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre University Hospital, Paris-Sud UniversityDepartment of Endocrinology Pediatric and Adult, Reference Center for Rare Genital Development Disorders, Lyon Hospices Civils, Est Hospital GroupDepartment of Endocrinology Pediatric and Adult, Reference Center for Rare Genital Development Disorders, Lyon Hospices Civils, Est Hospital GroupGynecology-Obstetrics and Reproductive Medicine Department, Assistance Publique-Hôpitaux de Paris, Tenon University HospitalDepartment of Endocrinology and Reproductive Diseases, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre University Hospital, Paris-Sud UniversityDepartment of Pediatric Endocrinology and Diabetology and Reference Center for Rare Diseases of Thyroid and Hormone Receptivity, Angers University HospitalAGAT, French Turner Syndrome Association (AGAT; Association Des Groupes Amitié Turner)Grandir Association (French Growth Disorders Association)Adolescent and Young Adult Gynecology Unit, Reference Center for Rare Genital Development Disorders, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre University Hospital, Paris-Sud UniversityReproductive Biology Department, Assistance Publique-Hôpitaux de Paris, Jean Verdier University HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalDepartment of Endocrinology and Metabolic Diseases, Caen University HospitalDepartment of Reproductive Medicine and Fertility Preservation, Assistance Publique-Hôpitaux de Paris, Antoine Béclère University HospitalReference Center for Rare Gynecological Pathologies, Pediatric Endocrinology Department, Assistance Publique-Hôpitaux de Paris, Université de Paris, Necker Enfants Malades University HospitalEndocrinology and Metabolism Department, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Saint Antoine HospitalEndocrinology and Metabolism Department, Brest University Hospital CentrePediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalPediatric Endocrinology, Lille University Jeanne de Flandre HospitalDepartment of Endocrinology, Toulouse University Paule Viguier HospitalClinical Genetics Department, DEV GEN Genital Development Reference Center, Lille University Jeanne de Flandre HospitalGenetics and Medical Gynecology Department, Reference Center for Rare Gynecological Pathologies, Toulouse University Hospitals - Hôpital Des Enfants, Pediatrics - EndocrinologyDepartment of Multidisciplinary Pediatrics, Reference Center for Pituitary Rare Diseases Aix Marseille University, Assistance Publique-Hôpitaux de Marseille, Hôpital de La Timone EnfantsDepartment of Endocrinology and Metabolic Diseases, Caen University HospitalGenetics and Embryology Department, Sorbonne Université; INSERM UMRS-933, Assistance Publique-Hôpitaux de Paris, Hôpital d’Enfants Armand-TrousseauGenetics Department, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalGenetics and Medical Gynecology Department, Toulouse University Hospital - Hôpital Des Enfants, Pediatrics - EndocrinologyPediatric Diabetology Department, Bordeaux University HospitalsClermont-Ferrand University Hospital, Endocrinology Department, Clermont Auvergne UniversityFrench Turner Syndrome Association (Turner Et Vous Association)Pediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalExplorations Fonctionnelles Endocriniennes, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Armand-Trousseau HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Université de Paris, Necker Enfants Malades University HospitalEndocrinology and Reproductive Medicine Department, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Pitié Salpétrière University HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalDepartment of Reproductive Endocrinology, Reference Center for Rare Growth and Development Endocrine Diseases, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Saint Antoine HospitalPediatric Endocrinology-Diabetology Department, Reference Center for Rare Growth and Development Endocrine Diseases, INSERM NeuroDiderot, Assistance Publique-Hôpitaux de Paris, Université de Paris, Robert Debré University HospitalAbstract Turner syndrome (TS; ORPHA 881) is a rare condition in which all or part of one X chromosome is absent from some or all cells. It affects approximately one in every 1/2500 liveborn girls. The most frequently observed karyotypes are 45,X (40–50%) and the 45,X/46,XX mosaic karyotype (15–25%). Karyotypes with an X isochromosome (45,X/46,isoXq or 45,X/46,isoXp), a Y chromosome, X ring chromosome or deletions of the X chromosome are less frequent. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins) is to provide health professionals with information about the optimal management and care for patients, based on a critical literature review and multidisciplinary expert consensus. The PNDS, written by members of the French National Reference Center for Rare Growth and Developmental Endocrine disorders, is available from the French Health Authority website. Turner Syndrome is associated with several phenotypic conditions and a higher risk of comorbidity. The most frequently reported features are growth retardation with short adult stature and gonadal dysgenesis. TS may be associated with various congenital (heart and kidney) or acquired diseases (autoimmune thyroid disease, celiac disease, hearing loss, overweight/obesity, glucose intolerance/type 2 diabetes, dyslipidemia, cardiovascular complications and liver dysfunction). Most of the clinical traits of TS are due to the haploinsufficiency of various genes on the X chromosome, particularly those in the pseudoautosomal regions (PAR 1 and PAR 2), which normally escape the physiological process of X inactivation, although other regions may also be implicated. The management of patients with TS requires collaboration between several healthcare providers. The attending physician, in collaboration with the national care network, will ensure that the patient receives optimal care through regular follow-up and screening. The various elements of this PNDS are designed to provide such support.https://doi.org/10.1186/s13023-022-02423-5Turner’s syndromeChildhoodAdulthoodDiagnosisRecommendationManagement |
| spellingShingle | Elodie Fiot Bertille Alauze Bruno Donadille Dinane Samara-Boustani Muriel Houang Gianpaolo De Filippo Anne Bachelot Clemence Delcour Constance Beyler Emilie Bois Emmanuelle Bourrat Emmanuel Bui Quoc Nathalie Bourcigaux Catherine Chaussain Ariel Cohen Martine Cohen-Solal Sabrina Da Costa Claire Dossier Stephane Ederhy Monique Elmaleh Laurence Iserin Hélène Lengliné Armelle Poujol-Robert Dominique Roulot Jerome Viala Frederique Albarel Elise Bismuth Valérie Bernard Claire Bouvattier Aude Brac Patricia Bretones Nathalie Chabbert-Buffet Philippe Chanson Regis Coutant Marguerite de Warren Béatrice Demaret Lise Duranteau Florence Eustache Lydie Gautheret Georges Gelwane Claire Gourbesville Mickaël Grynberg Karinne Gueniche Carina Jorgensen Veronique Kerlan Charlotte Lebrun Christine Lefevre Françoise Lorenzini Sylvie Manouvrier Catherine Pienkowski Rachel Reynaud Yves Reznik Jean-Pierre Siffroi Anne-Claude Tabet Maithé Tauber Vanessa Vautier Igor Tauveron Sebastien Wambre Delphine Zenaty Irène Netchine Michel Polak Philippe Touraine Jean-Claude Carel Sophie Christin-Maitre Juliane Léger Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol) Orphanet Journal of Rare Diseases Turner’s syndrome Childhood Adulthood Diagnosis Recommendation Management |
| title | Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol) |
| title_full | Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol) |
| title_fullStr | Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol) |
| title_full_unstemmed | Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol) |
| title_short | Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol) |
| title_sort | turner syndrome french national diagnosis and care protocol ndcp national diagnosis and care protocol |
| topic | Turner’s syndrome Childhood Adulthood Diagnosis Recommendation Management |
| url | https://doi.org/10.1186/s13023-022-02423-5 |
| work_keys_str_mv | AT elodiefiot turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT bertillealauze turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT brunodonadille turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT dinanesamaraboustani turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT murielhouang turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT gianpaolodefilippo turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT annebachelot turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT clemencedelcour turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT constancebeyler turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT emiliebois turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT emmanuellebourrat turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT emmanuelbuiquoc turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT nathaliebourcigaux turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT catherinechaussain turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT arielcohen turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT martinecohensolal turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT sabrinadacosta turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT clairedossier turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT stephaneederhy turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT moniqueelmaleh turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT laurenceiserin turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT helenelengline turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT armellepoujolrobert turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT dominiqueroulot turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT jeromeviala turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT frederiquealbarel turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT elisebismuth turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT valeriebernard turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT clairebouvattier turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT audebrac turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT patriciabretones turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT nathaliechabbertbuffet turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT philippechanson turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT regiscoutant turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT margueritedewarren turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT beatricedemaret turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT liseduranteau turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT florenceeustache turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT lydiegautheret turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT georgesgelwane turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT clairegourbesville turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT mickaelgrynberg turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT karinnegueniche turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT carinajorgensen turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT veroniquekerlan turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT charlottelebrun turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT christinelefevre turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT francoiselorenzini turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT sylviemanouvrier turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT catherinepienkowski turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT rachelreynaud turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT yvesreznik turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT jeanpierresiffroi turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT anneclaudetabet turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT maithetauber turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT vanessavautier turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT igortauveron turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT sebastienwambre turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT delphinezenaty turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT irenenetchine turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT michelpolak turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT philippetouraine turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT jeanclaudecarel turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT sophiechristinmaitre turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol AT julianeleger turnersyndromefrenchnationaldiagnosisandcareprotocolndcpnationaldiagnosisandcareprotocol |