Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation
Hyperlipidemia is associated with increased risk of the development of cardiovascular diseases. Although a great deal of attention has been paid to the hypolipidemic activity of fucoidan, complex polysaccharides from brown seaweeds, the underlying mechanism is still unclear. This study was performed...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-06-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861316300019 |
| _version_ | 1818310305641398272 |
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| author | Jinhee Park Mijung Yeom Dae-Hyun Hahm |
| author_facet | Jinhee Park Mijung Yeom Dae-Hyun Hahm |
| author_sort | Jinhee Park |
| collection | DOAJ |
| description | Hyperlipidemia is associated with increased risk of the development of cardiovascular diseases. Although a great deal of attention has been paid to the hypolipidemic activity of fucoidan, complex polysaccharides from brown seaweeds, the underlying mechanism is still unclear. This study was performed to investigate whether and how fucoidan has lipid-lowering potential in poloxamer-407 (P407)-induced hyperlipidemic mice. Fucoidan treatment 2 h after acute administration of P407 in these mice significantly reduced serum total cholesterol, triglycerides, and LDL cholesterol levels, but increased the levels of HDL cholesterol. In HepG2 hepatocytes and the liver, fucoidan decreased the expression of FAS and ACC mRNA with no or only a moderate inhibitory effect on SREBP-1c mRNA expression. Furthermore, fucoidan attenuated the hepatic expression of mature SREBP-2 protein with a subsequent decrease in hepatic HMG-CoA reductase mRNA expression and an increase in hepatic LDL receptor mRNA expression. In addition, atherosclerotic lesions in the aorta of chronically P407-treated mice were also reduced by fucoidan. These findings indicate that fucoidan improves serum lipid levels by regulating the expression of key enzymes of cholesterol and triglyceride syntheses in the liver through modulation of SREBP-2. |
| first_indexed | 2024-12-13T07:43:57Z |
| format | Article |
| id | doaj.art-47dc85b541da43ceaf9a32170d62386f |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-13T07:43:57Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-47dc85b541da43ceaf9a32170d62386f2022-12-21T23:54:53ZengElsevierJournal of Pharmacological Sciences1347-86132016-06-011312849210.1016/j.jphs.2016.03.007Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulationJinhee Park0Mijung Yeom1Dae-Hyun Hahm2Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of KoreaAcupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of KoreaAcupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of KoreaHyperlipidemia is associated with increased risk of the development of cardiovascular diseases. Although a great deal of attention has been paid to the hypolipidemic activity of fucoidan, complex polysaccharides from brown seaweeds, the underlying mechanism is still unclear. This study was performed to investigate whether and how fucoidan has lipid-lowering potential in poloxamer-407 (P407)-induced hyperlipidemic mice. Fucoidan treatment 2 h after acute administration of P407 in these mice significantly reduced serum total cholesterol, triglycerides, and LDL cholesterol levels, but increased the levels of HDL cholesterol. In HepG2 hepatocytes and the liver, fucoidan decreased the expression of FAS and ACC mRNA with no or only a moderate inhibitory effect on SREBP-1c mRNA expression. Furthermore, fucoidan attenuated the hepatic expression of mature SREBP-2 protein with a subsequent decrease in hepatic HMG-CoA reductase mRNA expression and an increase in hepatic LDL receptor mRNA expression. In addition, atherosclerotic lesions in the aorta of chronically P407-treated mice were also reduced by fucoidan. These findings indicate that fucoidan improves serum lipid levels by regulating the expression of key enzymes of cholesterol and triglyceride syntheses in the liver through modulation of SREBP-2.http://www.sciencedirect.com/science/article/pii/S1347861316300019HyperlipidemiaFucoidanPoloxamer-407HepG2 cellSterol regulatory element-binding protein-1c/2 |
| spellingShingle | Jinhee Park Mijung Yeom Dae-Hyun Hahm Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation Journal of Pharmacological Sciences Hyperlipidemia Fucoidan Poloxamer-407 HepG2 cell Sterol regulatory element-binding protein-1c/2 |
| title | Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation |
| title_full | Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation |
| title_fullStr | Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation |
| title_full_unstemmed | Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation |
| title_short | Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation |
| title_sort | fucoidan improves serum lipid levels and atherosclerosis through hepatic srebp 2 mediated regulation |
| topic | Hyperlipidemia Fucoidan Poloxamer-407 HepG2 cell Sterol regulatory element-binding protein-1c/2 |
| url | http://www.sciencedirect.com/science/article/pii/S1347861316300019 |
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