Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection
Summary: Long-term potentiation (LTP), which underlies learning and memory, can be induced by high-frequency electrical stimulation (HFS or HFES) and is thought to occur at the synapses of efferent projection. Here, the contralateral connectivity in mice auditory cortex was investigated to reveal th...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223006193 |
| _version_ | 1827966737613586432 |
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| author | Xiao Li Ling He Xiaohan Hu Fengwen Huang Xue Wang Mengying Chen Ezra Ginn Yoon Stephen Temitayo Bello Tao Chen Xi Chen Peng Tang Congping Chen Jianan Qu Jufang He |
| author_facet | Xiao Li Ling He Xiaohan Hu Fengwen Huang Xue Wang Mengying Chen Ezra Ginn Yoon Stephen Temitayo Bello Tao Chen Xi Chen Peng Tang Congping Chen Jianan Qu Jufang He |
| author_sort | Xiao Li |
| collection | DOAJ |
| description | Summary: Long-term potentiation (LTP), which underlies learning and memory, can be induced by high-frequency electrical stimulation (HFS or HFES) and is thought to occur at the synapses of efferent projection. Here, the contralateral connectivity in mice auditory cortex was investigated to reveal the fundamental corticocortical connection properties. After HFES, plasticity was not observed at the terminal synapses at the recording site. The optogenetic HFS at the recording site of the interhemispheric cortical projections could not induce LTP, but HFES at the recording site could induce the interhemispheric cortical LTP. Our subsequent results uncovered that it is the cholecystokinin (CCK) released from the entorhino-neocortical pathway induced by HEFS that modulates the neuroplasticity of the afferent projections, including interhemispheric auditory cortical afferents. Our study illustrates a heterosynaptic mechanism as the basis for cortical plasticity. This regulation might contribute new spots for the understanding and treatment of neurological disorders. |
| first_indexed | 2024-04-09T17:53:30Z |
| format | Article |
| id | doaj.art-47dcc2766d944ca5947e6434173195d0 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T17:53:30Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-47dcc2766d944ca5947e6434173195d02023-04-15T05:53:59ZengElsevieriScience2589-00422023-04-01264106542Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projectionXiao Li0Ling He1Xiaohan Hu2Fengwen Huang3Xue Wang4Mengying Chen5Ezra Ginn Yoon6Stephen Temitayo Bello7Tao Chen8Xi Chen9Peng Tang10Congping Chen11Jianan Qu12Jufang He13Department of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong; City University of Hong Kong Shenzhen Research Institute, Shenzhen, China; Corresponding authorDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong; City University of Hong Kong Shenzhen Research Institute, Shenzhen, ChinaDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong SAR, P.R. ChinaDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, Hong KongDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, Hong Kong; State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, ChinaDepartment of Neuroscience, City University of Hong Kong, Kowloon Tong, Hong Kong; City University of Hong Kong Shenzhen Research Institute, Shenzhen, China; Corresponding authorSummary: Long-term potentiation (LTP), which underlies learning and memory, can be induced by high-frequency electrical stimulation (HFS or HFES) and is thought to occur at the synapses of efferent projection. Here, the contralateral connectivity in mice auditory cortex was investigated to reveal the fundamental corticocortical connection properties. After HFES, plasticity was not observed at the terminal synapses at the recording site. The optogenetic HFS at the recording site of the interhemispheric cortical projections could not induce LTP, but HFES at the recording site could induce the interhemispheric cortical LTP. Our subsequent results uncovered that it is the cholecystokinin (CCK) released from the entorhino-neocortical pathway induced by HEFS that modulates the neuroplasticity of the afferent projections, including interhemispheric auditory cortical afferents. Our study illustrates a heterosynaptic mechanism as the basis for cortical plasticity. This regulation might contribute new spots for the understanding and treatment of neurological disorders.http://www.sciencedirect.com/science/article/pii/S2589004223006193Cellular neurosciencePhysiologySensory neuroscience |
| spellingShingle | Xiao Li Ling He Xiaohan Hu Fengwen Huang Xue Wang Mengying Chen Ezra Ginn Yoon Stephen Temitayo Bello Tao Chen Xi Chen Peng Tang Congping Chen Jianan Qu Jufang He Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection iScience Cellular neuroscience Physiology Sensory neuroscience |
| title | Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection |
| title_full | Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection |
| title_fullStr | Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection |
| title_full_unstemmed | Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection |
| title_short | Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection |
| title_sort | interhemispheric cortical long term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection |
| topic | Cellular neuroscience Physiology Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223006193 |
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