Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents
Abstract Objectives FTO rs9939609 variant has been shown to be associated with insulin resistance in Caucasian children. However, studies in Asia show inconsistent findings. We investigated the association between FTO rs9939609 polymorphisms and insulin resistance in obese female adolescents in Indo...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3392-8 |
| _version_ | 1818175344065118208 |
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| author | Kristy Iskandar Suryono Yudha Patria Emy Huriyati Harry Freitag Luglio Madarina Julia Rina Susilowati |
| author_facet | Kristy Iskandar Suryono Yudha Patria Emy Huriyati Harry Freitag Luglio Madarina Julia Rina Susilowati |
| author_sort | Kristy Iskandar |
| collection | DOAJ |
| description | Abstract Objectives FTO rs9939609 variant has been shown to be associated with insulin resistance in Caucasian children. However, studies in Asia show inconsistent findings. We investigated the association between FTO rs9939609 polymorphisms and insulin resistance in obese female adolescents in Indonesia, a genetically distinct group within Asia. Results A total of 78 obese female adolescents participated in this study. The risk allele (A) frequency of FTO rs9939609 variant in Indonesian obese female adolescence was 44.2%. The frequency of insulin resistance was higher in the subjects with AA (54.6%) or AT (59.6%) than the subject with TT genotype (50%), but did not statistically different (p = 0.81 and p = 0.47, respectively). The insulin resistance rate was also higher in the risk allele (A) than the non-risk allele (T) subjects (0.58 vs. 0.55), but did not statistically different (p = 0.75). There was no association between FTO rs9939609 variant and body mass index, fasting glucose level, fasting insulin level, homeostatic model assessment of insulin resistance, and waist circumference (p > 0.05). In conclusion, FTO rs9939609 variant may not be associated with insulin resistance in Indonesian obese female adolescents. A multicenter study with a larger sample size is needed to clarify these findings. |
| first_indexed | 2024-12-11T19:58:48Z |
| format | Article |
| id | doaj.art-47df1e0f2f0c44c7b7cbbae5d9569a18 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-11T19:58:48Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-47df1e0f2f0c44c7b7cbbae5d9569a182022-12-22T00:52:34ZengBMCBMC Research Notes1756-05002018-05-011111510.1186/s13104-018-3392-8Effect of FTO rs9939609 variant on insulin resistance in obese female adolescentsKristy Iskandar0Suryono Yudha Patria1Emy Huriyati2Harry Freitag Luglio3Madarina Julia4Rina Susilowati5Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada/UGM Academic HospitalDepartment of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito HospitalDepartment of Nutrition and Health, Faculty of Medicine, Universitas Gadjah MadaDepartment of Nutrition and Health, Faculty of Medicine, Universitas Gadjah MadaDepartment of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito HospitalDepartment of Histology and Cell Biology, Faculty of Medicine, Universitas Gadjah MadaAbstract Objectives FTO rs9939609 variant has been shown to be associated with insulin resistance in Caucasian children. However, studies in Asia show inconsistent findings. We investigated the association between FTO rs9939609 polymorphisms and insulin resistance in obese female adolescents in Indonesia, a genetically distinct group within Asia. Results A total of 78 obese female adolescents participated in this study. The risk allele (A) frequency of FTO rs9939609 variant in Indonesian obese female adolescence was 44.2%. The frequency of insulin resistance was higher in the subjects with AA (54.6%) or AT (59.6%) than the subject with TT genotype (50%), but did not statistically different (p = 0.81 and p = 0.47, respectively). The insulin resistance rate was also higher in the risk allele (A) than the non-risk allele (T) subjects (0.58 vs. 0.55), but did not statistically different (p = 0.75). There was no association between FTO rs9939609 variant and body mass index, fasting glucose level, fasting insulin level, homeostatic model assessment of insulin resistance, and waist circumference (p > 0.05). In conclusion, FTO rs9939609 variant may not be associated with insulin resistance in Indonesian obese female adolescents. A multicenter study with a larger sample size is needed to clarify these findings.http://link.springer.com/article/10.1186/s13104-018-3392-8Common variantFTOrs9939609IndonesiaInsulin resistanceObese female adolescents |
| spellingShingle | Kristy Iskandar Suryono Yudha Patria Emy Huriyati Harry Freitag Luglio Madarina Julia Rina Susilowati Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents BMC Research Notes Common variant FTO rs9939609 Indonesia Insulin resistance Obese female adolescents |
| title | Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents |
| title_full | Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents |
| title_fullStr | Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents |
| title_full_unstemmed | Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents |
| title_short | Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents |
| title_sort | effect of fto rs9939609 variant on insulin resistance in obese female adolescents |
| topic | Common variant FTO rs9939609 Indonesia Insulin resistance Obese female adolescents |
| url | http://link.springer.com/article/10.1186/s13104-018-3392-8 |
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