Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics

Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics

Abstract Recent studies show that rare, deleterious variants (RDVs) in certain genes are critical determinants of heritable cancer risk. To more comprehensively understand RDVs, we performed the largest-to-date germline variant calling analysis in a case-control setting for a multi-cancer associatio...

Полное описание

Библиографические подробности
Главные авторы:	Myvizhi Esai Selvan, Kenan Onel, Sacha Gnjatic, Robert J. Klein, Zeynep H. Gümüş
Формат:	Статья
Язык:	English
Опубликовано:	Nature Portfolio 2023-01-01
Серии:	npj Precision Oncology
Online-ссылка:	https://doi.org/10.1038/s41698-023-00354-3

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