Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study
Background: Tamsulosin is an inhibitory factor of alpha-adrenergic receptors that is used for relieving of the clinical symptoms and management of acute urinary retention. Objective: The aim of this study was to evaluate the effects of tamsulosin on the endocrine axis and testicular tissue in adult...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2020-07-01
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| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/ijrm.v13i7.7370 |
| _version_ | 1818108621891829760 |
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| author | Yegane Kohestani Bentolhoda Kohestani Zahra Shirmohamadi Masoumeh Faghani |
| author_facet | Yegane Kohestani Bentolhoda Kohestani Zahra Shirmohamadi Masoumeh Faghani |
| author_sort | Yegane Kohestani |
| collection | DOAJ |
| description | Background: Tamsulosin is an inhibitory factor of alpha-adrenergic receptors that is used for relieving of the clinical symptoms and management of acute urinary retention.
Objective: The aim of this study was to evaluate the effects of tamsulosin on the endocrine axis and testicular tissue in adult male rats.
Materials and Methods: In this experimental study, 30 adult male Wistar rats (weighing 250-300 gr) were divided into three groups: 1) control (received distilled water), 2) experimental 1 (received 0.2 mg/kg/day tamsulosin) and 3) experimental 2 (received 0.4 mg/kg/day tamsulosin) through oral gavage for 28 days. Serum hormones level and testicular histopathology were evaluated at the end of the experiment.
Results: In this study, the testicular weight decreased significantly in the experimental groups compared to the control group. A significant decrease was seen in testicular weight (p = 0.004) and the number of Leydig cells in tamsulosin-treated groups (p = 0.012). Tamsulosin improved the hormone profile in experimental groups. Also, higher dose of tamsulosin significantly changed the number of Leydig, spermatogonia cells, the thickness of germinal layer, and the diameter of the seminiferous tubules.
Conclusion: Results showed that using tamsulosin, possibly reduces the testosterone concentration through adrenergic axis system and in turn has destructive effects on proliferative activity of germ cells. |
| first_indexed | 2024-12-11T02:18:17Z |
| format | Article |
| id | doaj.art-47e1bbda087e48dc82b6ff312ea5f301 |
| institution | Directory Open Access Journal |
| issn | 2476-3772 |
| language | English |
| last_indexed | 2024-12-11T02:18:17Z |
| publishDate | 2020-07-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-47e1bbda087e48dc82b6ff312ea5f3012022-12-22T01:24:07ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-37722020-07-011853153810.18502/ijrm.v13i7.7370ijrm.v13i7.7370Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental studyYegane Kohestani0Bentolhoda Kohestani1Zahra Shirmohamadi2Masoumeh Faghani3 Department of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Background: Tamsulosin is an inhibitory factor of alpha-adrenergic receptors that is used for relieving of the clinical symptoms and management of acute urinary retention. Objective: The aim of this study was to evaluate the effects of tamsulosin on the endocrine axis and testicular tissue in adult male rats. Materials and Methods: In this experimental study, 30 adult male Wistar rats (weighing 250-300 gr) were divided into three groups: 1) control (received distilled water), 2) experimental 1 (received 0.2 mg/kg/day tamsulosin) and 3) experimental 2 (received 0.4 mg/kg/day tamsulosin) through oral gavage for 28 days. Serum hormones level and testicular histopathology were evaluated at the end of the experiment. Results: In this study, the testicular weight decreased significantly in the experimental groups compared to the control group. A significant decrease was seen in testicular weight (p = 0.004) and the number of Leydig cells in tamsulosin-treated groups (p = 0.012). Tamsulosin improved the hormone profile in experimental groups. Also, higher dose of tamsulosin significantly changed the number of Leydig, spermatogonia cells, the thickness of germinal layer, and the diameter of the seminiferous tubules. Conclusion: Results showed that using tamsulosin, possibly reduces the testosterone concentration through adrenergic axis system and in turn has destructive effects on proliferative activity of germ cells.https://doi.org/10.18502/ijrm.v13i7.7370tamsulosin, seminiferous tubules, histopathology, rat, testis. |
| spellingShingle | Yegane Kohestani Bentolhoda Kohestani Zahra Shirmohamadi Masoumeh Faghani Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study International Journal of Reproductive BioMedicine tamsulosin, seminiferous tubules, histopathology, rat, testis. |
| title | Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study |
| title_full | Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study |
| title_fullStr | Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study |
| title_full_unstemmed | Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study |
| title_short | Effect of tamsulosin on testis histopathology and serum hormones in adult rats: Experimental study |
| title_sort | effect of tamsulosin on testis histopathology and serum hormones in adult rats experimental study |
| topic | tamsulosin, seminiferous tubules, histopathology, rat, testis. |
| url | https://doi.org/10.18502/ijrm.v13i7.7370 |
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