Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder
Objective: The literature provides very limited information on mirtazapine usage in the pregnancy period. The groups including pregnant women who used SSRI or mirtazapine as a single treatment, SSRI–mirtazapine combination treatment and unmedicated groups were compared with respect to illness severi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AVES
2019-10-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/24750573.2019.1673936 |
| _version_ | 1797913748403388416 |
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| author | Buket Belkız Güngör Nalan Öztürk Ayça Öngel Atar Nazan Aydın |
| author_facet | Buket Belkız Güngör Nalan Öztürk Ayça Öngel Atar Nazan Aydın |
| author_sort | Buket Belkız Güngör |
| collection | DOAJ |
| description | Objective: The literature provides very limited information on mirtazapine usage in the pregnancy period. The groups including pregnant women who used SSRI or mirtazapine as a single treatment, SSRI–mirtazapine combination treatment and unmedicated groups were compared with respect to illness severity and birth outcomes. Method: The study sample included 120 pregnant women; 40 women with SSRI usage, 16 women with mirtazapine usage, 18 women with combined SSRI- mirtazapine usage, 23 women with unmedicated psychiatric disorder and who elected not to take medication during their pregnancy or discontinued antidepressants by themselves, and 23 healthy control women. Results: No difference was obtained with regard to the gestation week of birth, birth weight, the duration of stay in the neonatal care unit among the SSRI, mirtazapine, SSRI–mirtazapine combination, unmedicated patient and control groups. The likelihood of a new diagnosis was highest in the mirtazapine group. The majority of pregnant women whose psychiatric disorders were more severe and more relapsed used SSRI–mirtazapine combination treatment. Conclusion: No difference was observed between the SSRI and mirtazapine usage in the pregnancy period with regard to the birth outcomes. Similar birth outcomes could present clinicians with the option of prescribing mirtazapine as a safe alternative to SSRI in the treatment of antenatal psychiatric patients. |
| first_indexed | 2024-04-10T12:16:38Z |
| format | Article |
| id | doaj.art-47e3dc31fbe2452e97eb0ed3668dc040 |
| institution | Directory Open Access Journal |
| issn | 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T12:16:38Z |
| publishDate | 2019-10-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-47e3dc31fbe2452e97eb0ed3668dc0402023-02-15T16:15:43ZengAVESPsychiatry and Clinical Psychopharmacology2475-05812019-10-0129482283110.1080/24750573.2019.16739361673936Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorderBuket Belkız Güngör0Nalan Öztürk1Ayça Öngel Atar2Nazan Aydın3University of Health Sciences Istanbul Mazhar Osman Bakırkoy Mental Health and Neurological Diseases Training and Research HospitalUniversity of Health Sciences Istanbul Mazhar Osman Bakırkoy Mental Health and Neurological Diseases Training and Research HospitalUniversity of Health Sciences Istanbul Mazhar Osman Bakırkoy Mental Health and Neurological Diseases Training and Research HospitalÜsküdar University, PsychologyObjective: The literature provides very limited information on mirtazapine usage in the pregnancy period. The groups including pregnant women who used SSRI or mirtazapine as a single treatment, SSRI–mirtazapine combination treatment and unmedicated groups were compared with respect to illness severity and birth outcomes. Method: The study sample included 120 pregnant women; 40 women with SSRI usage, 16 women with mirtazapine usage, 18 women with combined SSRI- mirtazapine usage, 23 women with unmedicated psychiatric disorder and who elected not to take medication during their pregnancy or discontinued antidepressants by themselves, and 23 healthy control women. Results: No difference was obtained with regard to the gestation week of birth, birth weight, the duration of stay in the neonatal care unit among the SSRI, mirtazapine, SSRI–mirtazapine combination, unmedicated patient and control groups. The likelihood of a new diagnosis was highest in the mirtazapine group. The majority of pregnant women whose psychiatric disorders were more severe and more relapsed used SSRI–mirtazapine combination treatment. Conclusion: No difference was observed between the SSRI and mirtazapine usage in the pregnancy period with regard to the birth outcomes. Similar birth outcomes could present clinicians with the option of prescribing mirtazapine as a safe alternative to SSRI in the treatment of antenatal psychiatric patients.http://dx.doi.org/10.1080/24750573.2019.1673936ssrimirtazapinebirth weekbirth weightbirth outcomesillness severity |
| spellingShingle | Buket Belkız Güngör Nalan Öztürk Ayça Öngel Atar Nazan Aydın Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder Psychiatry and Clinical Psychopharmacology ssri mirtazapine birth week birth weight birth outcomes illness severity |
| title | Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder |
| title_full | Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder |
| title_fullStr | Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder |
| title_full_unstemmed | Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder |
| title_short | Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder |
| title_sort | comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder |
| topic | ssri mirtazapine birth week birth weight birth outcomes illness severity |
| url | http://dx.doi.org/10.1080/24750573.2019.1673936 |
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