Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier
The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nano...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/8/1997 |
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| author | Elena L. Krasnopeeva Elena Yu. Melenevskaya Larisa G. Klapshina Natalia Yu. Shilyagina Irina V. Balalaeva Nikolay N. Smirnov Michael A. Smirnov Alexander V. Yakimansky |
| author_facet | Elena L. Krasnopeeva Elena Yu. Melenevskaya Larisa G. Klapshina Natalia Yu. Shilyagina Irina V. Balalaeva Nikolay N. Smirnov Michael A. Smirnov Alexander V. Yakimansky |
| author_sort | Elena L. Krasnopeeva |
| collection | DOAJ |
| description | The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nanocontainers for the delivery of drug to tumor. For this purpose, two derivatives of porphyrazine suitable for photodynamic cancer therapy were loaded into prepared polymer brush. Fluorescence imaging was applied for monitoring of accumulation of porphyrazine in the CT26 murine colon carcinoma. The selective accumulation of cellulose brush loaded with porphyrazine in tumor was demonstrated by fluorescence intensity contrast between the tumor area and normal tissues. The tumor growth rate after photodynamic therapy were assessed and inhibition of its growth was revealed. |
| first_indexed | 2024-03-10T08:32:06Z |
| format | Article |
| id | doaj.art-47e6e0d70c8949c79084d26c6587fa10 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T08:32:06Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-47e6e0d70c8949c79084d26c6587fa102023-11-22T08:58:53ZengMDPI AGNanomaterials2079-49912021-08-01118199710.3390/nano11081997Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine CarrierElena L. Krasnopeeva0Elena Yu. Melenevskaya1Larisa G. Klapshina2Natalia Yu. Shilyagina3Irina V. Balalaeva4Nikolay N. Smirnov5Michael A. Smirnov6Alexander V. Yakimansky7Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 Saint Petersburg, RussiaInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 Saint Petersburg, RussiaRazuvaev Institute of Organomettalic Chemistry, Russian Academy of Sciences, 603137 Nizhniy Novgorod, RussiaInstitute of Biology and Biomedicine, Nizhniy Novgorod State University, 603950 Nizhniy Novgorod, RussiaInstitute of Biology and Biomedicine, Nizhniy Novgorod State University, 603950 Nizhniy Novgorod, RussiaInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 Saint Petersburg, RussiaInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 Saint Petersburg, RussiaInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 Saint Petersburg, RussiaThe prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nanocontainers for the delivery of drug to tumor. For this purpose, two derivatives of porphyrazine suitable for photodynamic cancer therapy were loaded into prepared polymer brush. Fluorescence imaging was applied for monitoring of accumulation of porphyrazine in the CT26 murine colon carcinoma. The selective accumulation of cellulose brush loaded with porphyrazine in tumor was demonstrated by fluorescence intensity contrast between the tumor area and normal tissues. The tumor growth rate after photodynamic therapy were assessed and inhibition of its growth was revealed.https://www.mdpi.com/2079-4991/11/8/1997cellulose brushATRPPDTdrug carrierporphyrazine |
| spellingShingle | Elena L. Krasnopeeva Elena Yu. Melenevskaya Larisa G. Klapshina Natalia Yu. Shilyagina Irina V. Balalaeva Nikolay N. Smirnov Michael A. Smirnov Alexander V. Yakimansky Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier Nanomaterials cellulose brush ATRP PDT drug carrier porphyrazine |
| title | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
| title_full | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
| title_fullStr | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
| title_full_unstemmed | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
| title_short | Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier |
| title_sort | poly methacrylic acid cellulose brushes as anticancer porphyrazine carrier |
| topic | cellulose brush ATRP PDT drug carrier porphyrazine |
| url | https://www.mdpi.com/2079-4991/11/8/1997 |
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