Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study
Background and purpose Cerebrovascular parenchymal damage is prevalent in ageing brains; however, its vascular aetiology has not been fully elucidated. In addition to the underlying role of sclerotic arterioles, the correlation between collagenised venules has not been clarified. Here, we aimed to i...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
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| Series: | Stroke and Vascular Neurology |
| Online Access: | https://svn.bmj.com/content/early/2022/12/28/svn-2022-001924.full |
| _version_ | 1797785025511424000 |
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| author | Xue Wang Chao Ma Yi-Cheng Zhu Yuan Cao Mei-Ying Huang Chen-Hui Mao Yuan-Yuan Xu Xiao-Jing Qian Wen-Ying Qiu |
| author_facet | Xue Wang Chao Ma Yi-Cheng Zhu Yuan Cao Mei-Ying Huang Chen-Hui Mao Yuan-Yuan Xu Xiao-Jing Qian Wen-Ying Qiu |
| author_sort | Xue Wang |
| collection | DOAJ |
| description | Background and purpose Cerebrovascular parenchymal damage is prevalent in ageing brains; however, its vascular aetiology has not been fully elucidated. In addition to the underlying role of sclerotic arterioles, the correlation between collagenised venules has not been clarified. Here, we aimed to investigate the associations between microvascular injuries, including arteriolosclerosis and venular collagenosis, and related parenchymal damages in ageing brains, to investigate the underlying correlations.Methods We evaluated arteriolosclerosis and venular collagenosis in 7 regions from 27 autopsy cases with no history of stroke or brain tumour. The correlations between the ratio of arteriolosclerosis, venular collagenosis and the severity of cerebrovascular parenchymal damage, including lacunes, microinfarcts, myelin loss, and parenchymal and perivascular haemosiderin deposits, were assessed.Results Arteriolosclerosis and venular collagenosis became more evident with age. Arteriolosclerosis was associated with lacunes (p=0.004) and brain parenchymal haemosiderin deposits in the superior frontal cortex (p=0.024) but not with leukoaraiosis severity. Venular collagenosis was not associated with the number of lacunes or haemosiderin, while white matter generally became paler with severe venular collagenosis in the periventricular (β=−0.430, p=0.028) and deep white matter (β=−0.437, p=0.025).Conclusion Our findings imply an important role for venular lesions in relation to microvessel-related parenchymal damage which is different from that for arteriolosclerosis. Different underlying mechanisms of both cerebral arterioles and venules require further investigation. |
| first_indexed | 2024-03-13T00:48:18Z |
| format | Article |
| id | doaj.art-47e77a236fdc4160a3e0bb9db6dab905 |
| institution | Directory Open Access Journal |
| issn | 2059-8696 |
| language | English |
| last_indexed | 2024-03-13T00:48:18Z |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Stroke and Vascular Neurology |
| spelling | doaj.art-47e77a236fdc4160a3e0bb9db6dab9052023-07-08T09:30:07ZengBMJ Publishing GroupStroke and Vascular Neurology2059-869610.1136/svn-2022-001924Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based studyXue Wang0Chao Ma1Yi-Cheng Zhu2Yuan Cao3Mei-Ying Huang4Chen-Hui Mao5Yuan-Yuan Xu6Xiao-Jing Qian7Wen-Ying Qiu8Medical Library, Xuanwu Hospital, Capital Medical University, Beijing, China2 Dana-Farber Cancer Institute, Boston, Massachusetts, USADepartment of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Gynecology and ObstetricsDepartment of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaDepartment of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaDepartment of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaBackground and purpose Cerebrovascular parenchymal damage is prevalent in ageing brains; however, its vascular aetiology has not been fully elucidated. In addition to the underlying role of sclerotic arterioles, the correlation between collagenised venules has not been clarified. Here, we aimed to investigate the associations between microvascular injuries, including arteriolosclerosis and venular collagenosis, and related parenchymal damages in ageing brains, to investigate the underlying correlations.Methods We evaluated arteriolosclerosis and venular collagenosis in 7 regions from 27 autopsy cases with no history of stroke or brain tumour. The correlations between the ratio of arteriolosclerosis, venular collagenosis and the severity of cerebrovascular parenchymal damage, including lacunes, microinfarcts, myelin loss, and parenchymal and perivascular haemosiderin deposits, were assessed.Results Arteriolosclerosis and venular collagenosis became more evident with age. Arteriolosclerosis was associated with lacunes (p=0.004) and brain parenchymal haemosiderin deposits in the superior frontal cortex (p=0.024) but not with leukoaraiosis severity. Venular collagenosis was not associated with the number of lacunes or haemosiderin, while white matter generally became paler with severe venular collagenosis in the periventricular (β=−0.430, p=0.028) and deep white matter (β=−0.437, p=0.025).Conclusion Our findings imply an important role for venular lesions in relation to microvessel-related parenchymal damage which is different from that for arteriolosclerosis. Different underlying mechanisms of both cerebral arterioles and venules require further investigation.https://svn.bmj.com/content/early/2022/12/28/svn-2022-001924.full |
| spellingShingle | Xue Wang Chao Ma Yi-Cheng Zhu Yuan Cao Mei-Ying Huang Chen-Hui Mao Yuan-Yuan Xu Xiao-Jing Qian Wen-Ying Qiu Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study Stroke and Vascular Neurology |
| title | Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study |
| title_full | Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study |
| title_fullStr | Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study |
| title_full_unstemmed | Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study |
| title_short | Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study |
| title_sort | arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages an autopsy based study |
| url | https://svn.bmj.com/content/early/2022/12/28/svn-2022-001924.full |
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