USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response.

USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response.

Type I interferons (IFN) are cytokines that are rapidly secreted upon microbial infections and regulate all aspects of the immune response. In humans 15 type I IFN subtypes exist, of which IFN α2 and IFN β are used in the clinic for treatment of different pathologies. IFN α2 and IFN β are non redund...

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Bibliographic Details
Main Authors: Véronique François-Newton, Gabriel Magno de Freitas Almeida, Béatrice Payelle-Brogard, Danièle Monneron, Lydiane Pichard-Garcia, Jacob Piehler, Sandra Pellegrini, Gilles Uzé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3136508?pdf=render

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