MDM2 Amplified Sarcomas: A Literature Review
Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/3/496 |
| _version_ | 1797541749327921152 |
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| author | Raf Sciot |
| author_facet | Raf Sciot |
| author_sort | Raf Sciot |
| collection | DOAJ |
| description | Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors. |
| first_indexed | 2024-03-10T13:20:12Z |
| format | Article |
| id | doaj.art-47e866a0551641ad8532832718942e08 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T13:20:12Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-47e866a0551641ad8532832718942e082023-11-21T10:05:28ZengMDPI AGDiagnostics2075-44182021-03-0111349610.3390/diagnostics11030496MDM2 Amplified Sarcomas: A Literature ReviewRaf Sciot0Department of Pathology, University Hospital, University of Leuven, 3000 Leuven, BelgiumMurine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.https://www.mdpi.com/2075-4418/11/3/496MDM2 amplificationwell-differentiated liposarcoma/atypical lipomatous tumordedifferentiated liposarcomaintimal sarcoma low grade osteosarcoma |
| spellingShingle | Raf Sciot MDM2 Amplified Sarcomas: A Literature Review Diagnostics MDM2 amplification well-differentiated liposarcoma/atypical lipomatous tumor dedifferentiated liposarcoma intimal sarcoma low grade osteosarcoma |
| title | MDM2 Amplified Sarcomas: A Literature Review |
| title_full | MDM2 Amplified Sarcomas: A Literature Review |
| title_fullStr | MDM2 Amplified Sarcomas: A Literature Review |
| title_full_unstemmed | MDM2 Amplified Sarcomas: A Literature Review |
| title_short | MDM2 Amplified Sarcomas: A Literature Review |
| title_sort | mdm2 amplified sarcomas a literature review |
| topic | MDM2 amplification well-differentiated liposarcoma/atypical lipomatous tumor dedifferentiated liposarcoma intimal sarcoma low grade osteosarcoma |
| url | https://www.mdpi.com/2075-4418/11/3/496 |
| work_keys_str_mv | AT rafsciot mdm2amplifiedsarcomasaliteraturereview |